Gene Page: TIMP4

Summary ?
GeneID7079
SymbolTIMP4
Synonyms-
DescriptionTIMP metallopeptidase inhibitor 4
ReferenceMIM:601915|HGNC:HGNC:11823|Ensembl:ENSG00000157150|HPRD:03557|Vega:OTTHUMG00000129763
Gene typeprotein-coding
Map location3p25
Pascal p-value0.013
Fetal beta-0.975
eGeneFrontal Cortex BA9
Hypothalamus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2502827chr1176044216TIMP470790.12trans
rs17572651chr1218943612TIMP470792.206E-6trans
snp_a-19197940TIMP470790.01trans
rs16829545chr2151977407TIMP470791.015E-10trans
rs3845734chr2171125572TIMP470790trans
rs8179648chr2179377279TIMP470790.07trans
rs7584986chr2184111432TIMP470791.756E-18trans
rs6729020chr2189064719TIMP470790.07trans
rs6807632chr3111395567TIMP470790.12trans
rs10491487chr580323367TIMP470792.532E-7trans
rs1560919chr589587250TIMP470790.18trans
rs1368303chr5147672388TIMP470792.362E-9trans
rs1929769chr640765977TIMP470790trans
rs17071719chr6110793869TIMP470790.14trans
rs6989594chr8126303866TIMP470790.13trans
rs11139334chr984209393TIMP470790.01trans
rs12099529chr1278888019TIMP470790.07trans
rs7996604chr1342224412TIMP470790.14trans
snp_a-18805480TIMP470790.05trans
rs17104720chr1477127308TIMP470790.04trans
rs6574467chr1479179744TIMP470790trans
rs10146003chr1479191170TIMP470790trans
rs16955618chr1529937543TIMP470791.848E-28trans
snp_a-18308940TIMP470790trans
snp_a-21757550TIMP470790.02trans
rs16944856chr1711394566TIMP470790.1trans
rs17085767chr1869839397TIMP470793.644E-4trans
rs749043chr2046995700TIMP470790.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ICAM20.840.69
TMEM2040.790.67
GIMAP50.780.61
C10orf100.780.49
IL320.770.54
SH3TC10.740.53
CDC42EP50.700.72
HRCT10.700.32
GGT50.700.56
RRAS0.680.59
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GGNBP2-0.56-0.57
DNAJC7-0.55-0.53
DNM1L-0.54-0.53
AC141586.1-0.53-0.56
SLC4A1AP-0.53-0.49
TAOK3-0.53-0.51
MPHOSPH8-0.53-0.57
DDX42-0.53-0.51
RP11-298P3.1-0.52-0.55
SDCCAG1-0.52-0.56

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0004857enzyme inhibitor activityIEA-
GO:0008191metalloendopeptidase inhibitor activityNAS8939999 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS-
GO:0005578proteinaceous extracellular matrixIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 3927All SZGR 2.0 genes in this pathway
GOUYER TATI TARGETS DN 1712All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS UP 2114All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
SAGIV CD24 TARGETS DN 4626All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE UP 9761All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG DN 3722All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 8452All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 8066All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153107All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 8051All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 10467All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway