Gene Page: TSHB

Summary ?
GeneID7252
SymbolTSHB
SynonymsTSH-B|TSH-BETA
Descriptionthyroid stimulating hormone beta
ReferenceMIM:188540|HGNC:HGNC:12372|Ensembl:ENSG00000134200|HPRD:11766|
Gene typeprotein-coding
Map location1p13
Pascal p-value0.011

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NDUFS40.820.85
SEC61G0.780.75
ATP5O0.770.79
ATP5E0.760.77
C11orf730.760.78
C20orf240.760.71
NOP100.760.73
PHPT10.760.71
NTAN10.750.73
C11orf740.740.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MYH9-0.56-0.59
CASKIN2-0.50-0.60
FAM38A-0.46-0.54
PTRF-0.46-0.51
TRIM56-0.46-0.54
NPR1-0.45-0.52
PEAR1-0.45-0.52
MMRN2-0.45-0.48
SDPR-0.44-0.46
SHE-0.44-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityTAS2792087 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS2792087 
GO:0007267cell-cell signalingTAS2792087 
GO:0009653anatomical structure morphogenesisTAS2792087 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 5349All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY 3428All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME GLYCOPROTEIN HORMONES 128All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE HORMONE BIOSYNTHESIS 1410All SZGR 2.0 genes in this pathway
REACTOME AMINE DERIVED HORMONES 1512All SZGR 2.0 genes in this pathway
REACTOME HORMONE LIGAND BINDING RECEPTORS 108All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 8662All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 11371All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 3930All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY 2925All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway