Gene Page: CAPN5

Summary ?
GeneID726
SymbolCAPN5
SynonymsADNIV|HTRA3|VRNI|nCL-3
Descriptioncalpain 5
ReferenceMIM:602537|HGNC:HGNC:1482|Ensembl:ENSG00000149260|HPRD:03963|Vega:OTTHUMG00000165192
Gene typeprotein-coding
Map location11q14
Pascal p-value0.112
Fetal beta-0.282
SupportRNA AND PROTEIN SYNTHESIS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
CAPN5chr1176831955GANM_004055
NM_004055		.
p.496R>Q		splice
missense		SchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LUM0.860.73
ASPN0.860.81
ITIH20.840.84
ALDH1A20.820.83
COL3A10.820.38
OLFML30.820.58
LYVE10.800.83
TBX180.800.74
OGN0.800.90
BMP50.770.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACP6-0.23-0.12
SEPT12-0.22-0.33
AL022328.1-0.22-0.19
CHMP4A-0.21-0.33
SNHG12-0.21-0.39
AC132872.1-0.20-0.42
ZRSR2-0.19-0.34
AMY2B-0.18-0.12
LRRC37A-0.18-0.26
AC007216.4-0.18-0.21

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169118All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349157All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 8056All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER 5030All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 UP 8152All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 4833All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway