Gene Page: ZIC2

Summary
GeneID  7546
Symbol  ZIC2
Synonyms  HPE5
Description  Zic family member 2 (odd-paired homolog, Drosophila)
See related  HGNC:12873|MIM:603073|Ensembl:ENSG00000043355|HPRD:04353|
Locus tag  -
Gene type  protein-coding
Map location  13q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF30.970.94
SETDB10.960.93
SSRP10.960.93
RAF10.960.93
ZNF340.950.90
ZNF6710.950.92
ZNF8210.950.89
FAM48A0.950.91
BAT10.950.91
MTA20.950.92
Top 10 negatively co-expressed genes
AF347015.27-0.78-0.90
AF347015.31-0.77-0.89
HLA-F-0.77-0.77
MT-CO2-0.76-0.89
C5orf53-0.76-0.72
AIFM3-0.75-0.75
AF347015.33-0.75-0.86
MT-CYB-0.74-0.86
IFI27-0.74-0.85
S100B-0.74-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005249voltage-gated potassium channel activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentTASBrain (GO term level: 7)9771712 
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0006813potassium ion transportIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0008076voltage-gated potassium channel complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GLI1GLIglioma-associated oncogene homolog 1 (zinc finger protein)-HPRD,BioGRID11238441 
GLI2HPE9 | THP1 | THP2GLI-Kruppel family member GLI2-HPRD,BioGRID11238441 
GLI3ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIVGLI-Kruppel family member GLI3Affinity Capture-Western
Reconstituted Complex		BioGRID11238441 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_UP 2918All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_A 10063All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN 10364All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
NIELSEN_GIST_VS_SYNOVIAL_SARCOMA_UP 1912All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_DN 12071All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_UP 1814All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
MAEKAWA_ATF2_TARGETS 2419All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1817147211A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1826386441Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-30-5p7387441Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-485-3p7877941A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-493-5p9599661A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-494940946m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-505107010771A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-543938944m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-966376441A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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