Gene Page: TSEN34
Summary ?
| GeneID | 79042 |
| Symbol | TSEN34 |
| Synonyms | LENG5|PCH2C|SEN34|SEN34L |
| Description | tRNA splicing endonuclease subunit 34 |
| Reference | MIM:608754|HGNC:HGNC:15506|Ensembl:ENSG00000170892|HPRD:10038|Vega:OTTHUMG00000066515 |
| Gene type | protein-coding |
| Map location | 19q13.4 |
| Pascal p-value | 0.025 |
| Sherlock p-value | 0.501 |
| Fetal beta | 0.669 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11680855 | 19 | 54694179 | TSEN34 | 2.28E-10 | -0.017 | 5.98E-7 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4501739 | chrX | 35960848 | TSEN34 | 79042 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF529 | 0.93 | 0.93 |
| ZNF287 | 0.92 | 0.91 |
| ZNF268 | 0.91 | 0.93 |
| TOPORS | 0.91 | 0.94 |
| UBA6 | 0.91 | 0.93 |
| ZNF607 | 0.91 | 0.92 |
| ZZZ3 | 0.91 | 0.93 |
| ZNF564 | 0.90 | 0.91 |
| TGS1 | 0.90 | 0.92 |
| AGPAT5 | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.69 | -0.82 |
| AF347015.31 | -0.68 | -0.81 |
| AF347015.27 | -0.66 | -0.77 |
| FXYD1 | -0.66 | -0.79 |
| AF347015.33 | -0.66 | -0.77 |
| IFI27 | -0.66 | -0.80 |
| AF347015.8 | -0.65 | -0.79 |
| HLA-F | -0.65 | -0.71 |
| MT-CYB | -0.65 | -0.77 |
| HIGD1B | -0.64 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PROVENZANI METASTASIS DN | 136 | 94 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| PAL PRMT5 TARGETS UP | 203 | 135 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| MCCABE HOXC6 TARGETS CANCER DN | 20 | 12 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 DN | 315 | 201 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF DN | 235 | 144 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | 172 | 107 | All SZGR 2.0 genes in this pathway |