Gene Page: PAAF1
Summary ?
| GeneID | 80227 |
| Symbol | PAAF1 |
| Synonyms | PAAF|Rpn14|WDR71 |
| Description | proteasomal ATPase associated factor 1 |
| Reference | HGNC:HGNC:25687|Ensembl:ENSG00000175575|HPRD:07761|Vega:OTTHUMG00000168062 |
| Gene type | protein-coding |
| Map location | 11q13.4 |
| Pascal p-value | 0.126 |
| Sherlock p-value | 2.876E-5 |
| Fetal beta | -0.886 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4944889 | chr11 | 74098732 | PAAF1 | 80227 | 0.07 | cis | ||
| rs16868984 | chr4 | 19963186 | PAAF1 | 80227 | 0.06 | trans | ||
| rs2067912 | 11 | 73611349 | PAAF1 | ENSG00000175575.8 | 7.305E-9 | 0 | 23605 | gtex_brain_ba24 |
| rs7942963 | 11 | 73615599 | PAAF1 | ENSG00000175575.8 | 6.976E-9 | 0 | 27855 | gtex_brain_ba24 |
| rs60863026 | 11 | 73633779 | PAAF1 | ENSG00000175575.8 | 3.748E-9 | 0 | 46035 | gtex_brain_ba24 |
| rs60812833 | 11 | 73636213 | PAAF1 | ENSG00000175575.8 | 3.748E-9 | 0 | 48469 | gtex_brain_ba24 |
| rs117816201 | 11 | 73664450 | PAAF1 | ENSG00000175575.8 | 1.175E-9 | 0 | 76706 | gtex_brain_ba24 |
| rs147595668 | 11 | 73425033 | PAAF1 | ENSG00000175575.8 | 3.631E-7 | 0 | -162711 | gtex_brain_putamen_basal |
| rs117601018 | 11 | 73476067 | PAAF1 | ENSG00000175575.8 | 5.243E-7 | 0 | -111677 | gtex_brain_putamen_basal |
| rs79532972 | 11 | 73481247 | PAAF1 | ENSG00000175575.8 | 5.225E-7 | 0 | -106497 | gtex_brain_putamen_basal |
| rs148279230 | 11 | 73591656 | PAAF1 | ENSG00000175575.8 | 3.853E-7 | 0 | 3912 | gtex_brain_putamen_basal |
| rs2067912 | 11 | 73611349 | PAAF1 | ENSG00000175575.8 | 9.727E-14 | 0 | 23605 | gtex_brain_putamen_basal |
| rs7942963 | 11 | 73615599 | PAAF1 | ENSG00000175575.8 | 9.025E-14 | 0 | 27855 | gtex_brain_putamen_basal |
| rs76577804 | 11 | 73618470 | PAAF1 | ENSG00000175575.8 | 4.376E-7 | 0 | 30726 | gtex_brain_putamen_basal |
| rs60863026 | 11 | 73633779 | PAAF1 | ENSG00000175575.8 | 4.134E-13 | 0 | 46035 | gtex_brain_putamen_basal |
| rs60812833 | 11 | 73636213 | PAAF1 | ENSG00000175575.8 | 4.058E-13 | 0 | 48469 | gtex_brain_putamen_basal |
| rs183626835 | 11 | 73647693 | PAAF1 | ENSG00000175575.8 | 2.63E-6 | 0 | 59949 | gtex_brain_putamen_basal |
| rs117816201 | 11 | 73664450 | PAAF1 | ENSG00000175575.8 | 1.027E-10 | 0 | 76706 | gtex_brain_putamen_basal |
| rs10793069 | 11 | 73669334 | PAAF1 | ENSG00000175575.8 | 4.679E-7 | 0 | 81590 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ALDH16A1 | MGC10204 | aldehyde dehydrogenase 16 family, member A1 | Affinity Capture-MS | BioGRID | 17353931 |
| DERA | CGI-26 | DEOC | 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) | Affinity Capture-MS | BioGRID | 17353931 |
| FADS1 | D5D | FADS6 | FADSD5 | FLJ38956 | FLJ90273 | LLCDL1 | TU12 | fatty acid desaturase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC1 | MGC24583 | MGC8541 | P26S4 | S4 | p56 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC2 | MGC3004 | MSS1 | Nbla10058 | S7 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC3 | MGC8487 | TBP1 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC4 | MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC5 | S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUG | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC6 | CADP44 | MGC12520 | P44 | SUG2 | p42 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD1 | MGC133040 | MGC133041 | P112 | Rpn2 | S1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD10 | dJ889N15.2 | p28 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD11 | MGC3844 | Rpn6 | S9 | p44.5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD12 | MGC75406 | Rpn5 | p55 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD14 | PAD1 | POH1 | rpn11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD2 | MGC14274 | P97 | Rpn1 | S2 | TRAP2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD3 | P58 | RPN3 | S3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD6 | KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD7 | MOV34 | P40 | Rpn8 | S12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD8 | HIP6 | HYPF | MGC1660 | Nin1p | Rpn12 | S14 | p31 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | 70 | 38 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | All SZGR 2.0 genes in this pathway |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI DN | 73 | 45 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | 172 | 107 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS UP | 221 | 135 | All SZGR 2.0 genes in this pathway |