Gene Page: POLR2M

Summary ?
GeneID81488
SymbolPOLR2M
SynonymsGCOM1|GRINL1A|Gdown|Gdown1
Descriptionpolymerase (RNA) II subunit M
ReferenceMIM:606485|HGNC:HGNC:14862|Ensembl:ENSG00000255529|HPRD:07575|Vega:OTTHUMG00000166486
Gene typeprotein-coding
Map location15q21.3
Pascal p-value0.449
Sherlock p-value0.565
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KLHL180.870.92
SLC35C10.870.92
RUSC20.870.91
DISP20.860.89
TNPO20.850.88
ZNRF10.850.89
FAM123C0.850.88
ZNF3240.850.88
MAPT0.840.90
AMBRA10.840.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.67-0.76
AF347015.31-0.67-0.75
AF347015.33-0.66-0.74
FXYD1-0.66-0.73
AF347015.27-0.65-0.74
AC021016.1-0.65-0.76
AF347015.8-0.65-0.76
MT-CYB-0.64-0.73
S100B-0.64-0.72
COPZ2-0.63-0.70

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKHD1MASK | VBARPankyrin repeat and KH domain containing 1Two-hybridBioGRID16169070 
APOD-apolipoprotein DTwo-hybridBioGRID16169070 
CEBPGGPE1BP | IG/EBP-1CCAAT/enhancer binding protein (C/EBP), gammaTwo-hybridBioGRID16189514 
DGKZDAGK5 | DAGK6 | DGK-ZETA | hDGKzetadiacylglycerol kinase, zeta 104kDaTwo-hybridBioGRID16169070 
ERAFAHSP | EDRFerythroid associated factorTwo-hybridBioGRID16169070 
HIGD1BCLST11240 | CLST11240-15HIG1 domain family, member 1BTwo-hybridBioGRID16169070 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
MYO3ADFNB30myosin IIIATwo-hybridBioGRID16169070 
MYO9AFLJ11061 | FLJ13244 | MGC71859myosin IXATwo-hybridBioGRID16169070 
PSMC2MGC3004 | MSS1 | Nbla10058 | S7proteasome (prosome, macropain) 26S subunit, ATPase, 2Two-hybridBioGRID16169070 
RBM4BMGC10871 | RBM30 | RBM4L | ZCCHC15 | ZCRB3BRNA binding motif protein 4BTwo-hybridBioGRID16169070 
RPL7ASURF3 | TRUPribosomal protein L7aTwo-hybridBioGRID16169070 
SCMH1Scml3sex comb on midleg homolog 1 (Drosophila)Two-hybridBioGRID16169070 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1Two-hybridBioGRID16189514 
UQCRQQCR8 | QP-C | QPCubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDaTwo-hybridBioGRID16169070 
WDR89C14orf150 | MGC9907 | MSTP050WD repeat domain 89Two-hybridBioGRID16169070 
ZNF410APA-1 | APA1zinc finger protein 410Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
CASTELLANO HRAS AND NRAS TARGETS DN 86All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP 3319All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 15186All SZGR 2.0 genes in this pathway