Gene Page: NUDT12
Summary ?
| GeneID | 83594 |
| Symbol | NUDT12 |
| Synonyms | - |
| Description | nudix hydrolase 12 |
| Reference | MIM:609232|HGNC:HGNC:18826|Ensembl:ENSG00000112874|HPRD:10123|Vega:OTTHUMG00000128739 |
| Gene type | protein-coding |
| Map location | 5q21.2 |
| Pascal p-value | 0.025 |
| eGene | Frontal Cortex BA9 Nucleus accumbens basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11120206 | chr1 | 206610593 | NUDT12 | 83594 | 0.02 | trans | ||
| rs2716734 | chr2 | 39947720 | NUDT12 | 83594 | 0.13 | trans | ||
| rs2716736 | chr2 | 39947946 | NUDT12 | 83594 | 0.13 | trans | ||
| rs9882137 | chr3 | 29494146 | NUDT12 | 83594 | 0.13 | trans | ||
| rs16894557 | chr6 | 28999825 | NUDT12 | 83594 | 0.06 | trans | ||
| rs10124277 | chr9 | 8499294 | NUDT12 | 83594 | 0.06 | trans | ||
| rs7047051 | chr9 | 38020943 | NUDT12 | 83594 | 0.1 | trans | ||
| rs12255258 | chr10 | 106306927 | NUDT12 | 83594 | 0 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZC3H14 | 0.73 | 0.75 |
| RAD23B | 0.72 | 0.75 |
| TERF1 | 0.72 | 0.77 |
| TIAL1 | 0.72 | 0.76 |
| FBXO38 | 0.72 | 0.75 |
| EXT1 | 0.72 | 0.76 |
| COQ7 | 0.72 | 0.75 |
| CDC7 | 0.72 | 0.79 |
| CUL1 | 0.72 | 0.75 |
| VPS45 | 0.72 | 0.74 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.68 | -0.72 |
| AF347015.31 | -0.66 | -0.71 |
| MT-CYB | -0.66 | -0.70 |
| AF347015.8 | -0.66 | -0.70 |
| AF347015.33 | -0.65 | -0.68 |
| AF347015.2 | -0.64 | -0.67 |
| AF347015.26 | -0.64 | -0.67 |
| AF347015.27 | -0.63 | -0.69 |
| AF347015.15 | -0.63 | -0.68 |
| AF347015.21 | -0.62 | -0.68 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NICOTINATE AND NICOTINAMIDE METABOLISM | 24 | 16 | All SZGR 2.0 genes in this pathway |
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA PROGRESSION RISK | 74 | 44 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN | 321 | 200 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |