Gene Page: ZMIZ2
Summary ?
| GeneID | 83637 |
| Symbol | ZMIZ2 |
| Synonyms | NET27|TRAFIP20|ZIMP7|hZIMP7 |
| Description | zinc finger MIZ-type containing 2 |
| Reference | MIM:611196|HGNC:HGNC:22229|Ensembl:ENSG00000122515|HPRD:13225|Vega:OTTHUMG00000155817 |
| Gene type | protein-coding |
| Map location | 7p13 |
| Pascal p-value | 9.019E-4 |
| Sherlock p-value | 0.511 |
| eGene | Caudate basal ganglia Putamen basal ganglia Meta |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4720478 | 7 | 44784259 | ZMIZ2 | ENSG00000122515.10 | 5.067E-7 | 0 | -3921 | gtex_brain_putamen_basal |
| rs799449 | 7 | 44784697 | ZMIZ2 | ENSG00000122515.10 | 2.646E-7 | 0 | -3483 | gtex_brain_putamen_basal |
| rs10243354 | 7 | 44784864 | ZMIZ2 | ENSG00000122515.10 | 9.104E-7 | 0 | -3316 | gtex_brain_putamen_basal |
| rs10227940 | 7 | 44784866 | ZMIZ2 | ENSG00000122515.10 | 4.846E-7 | 0 | -3314 | gtex_brain_putamen_basal |
| rs6962280 | 7 | 44788657 | ZMIZ2 | ENSG00000122515.10 | 1.416E-8 | 0 | 477 | gtex_brain_putamen_basal |
| rs799451 | 7 | 44790988 | ZMIZ2 | ENSG00000122515.10 | 3.301E-7 | 0 | 2808 | gtex_brain_putamen_basal |
| rs799452 | 7 | 44792541 | ZMIZ2 | ENSG00000122515.10 | 2.646E-7 | 0 | 4361 | gtex_brain_putamen_basal |
| rs4724319 | 7 | 44803286 | ZMIZ2 | ENSG00000122515.10 | 1.108E-6 | 0 | 15106 | gtex_brain_putamen_basal |
| rs1050327 | 7 | 44808017 | ZMIZ2 | ENSG00000122515.10 | 2.286E-8 | 0 | 19837 | gtex_brain_putamen_basal |
| rs1050331 | 7 | 44808091 | ZMIZ2 | ENSG00000122515.10 | 2.097E-8 | 0 | 19911 | gtex_brain_putamen_basal |
| rs1050338 | 7 | 44808223 | ZMIZ2 | ENSG00000122515.10 | 5.194E-7 | 0 | 20043 | gtex_brain_putamen_basal |
| rs1065646 | 7 | 44809273 | ZMIZ2 | ENSG00000122515.10 | 4.208E-8 | 0 | 21093 | gtex_brain_putamen_basal |
| rs1065647 | 7 | 44809276 | ZMIZ2 | ENSG00000122515.10 | 2.59E-8 | 0 | 21096 | gtex_brain_putamen_basal |
| rs12534879 | 7 | 44810166 | ZMIZ2 | ENSG00000122515.10 | 3.855E-7 | 0 | 21986 | gtex_brain_putamen_basal |
| rs9655458 | 7 | 44810985 | ZMIZ2 | ENSG00000122515.10 | 3.008E-8 | 0 | 22805 | gtex_brain_putamen_basal |
| rs10252662 | 7 | 44811223 | ZMIZ2 | ENSG00000122515.10 | 3.448E-7 | 0 | 23043 | gtex_brain_putamen_basal |
| rs13224222 | 7 | 44812338 | ZMIZ2 | ENSG00000122515.10 | 3.426E-7 | 0 | 24158 | gtex_brain_putamen_basal |
| rs12702087 | 7 | 44812607 | ZMIZ2 | ENSG00000122515.10 | 3.287E-7 | 0 | 24427 | gtex_brain_putamen_basal |
| rs35307410 | 7 | 44814228 | ZMIZ2 | ENSG00000122515.10 | 3.644E-7 | 0 | 26048 | gtex_brain_putamen_basal |
| rs4724320 | 7 | 44815334 | ZMIZ2 | ENSG00000122515.10 | 3.695E-8 | 0 | 27154 | gtex_brain_putamen_basal |
| rs7806283 | 7 | 44818703 | ZMIZ2 | ENSG00000122515.10 | 1.174E-6 | 0 | 30523 | gtex_brain_putamen_basal |
| rs10264096 | 7 | 44819444 | ZMIZ2 | ENSG00000122515.10 | 1.751E-6 | 0 | 31264 | gtex_brain_putamen_basal |
| rs10264405 | 7 | 44819494 | ZMIZ2 | ENSG00000122515.10 | 1.769E-6 | 0 | 31314 | gtex_brain_putamen_basal |
| rs200205267 | 7 | 44822730 | ZMIZ2 | ENSG00000122515.10 | 1.857E-6 | 0 | 34550 | gtex_brain_putamen_basal |
| rs7809515 | 7 | 44822731 | ZMIZ2 | ENSG00000122515.10 | 6.285E-7 | 0 | 34551 | gtex_brain_putamen_basal |
| rs13236827 | 7 | 44833065 | ZMIZ2 | ENSG00000122515.10 | 1.651E-6 | 0 | 44885 | gtex_brain_putamen_basal |
| rs10275962 | 7 | 44848740 | ZMIZ2 | ENSG00000122515.10 | 9.45E-7 | 0 | 60560 | gtex_brain_putamen_basal |
| rs13238404 | 7 | 44851411 | ZMIZ2 | ENSG00000122515.10 | 4.399E-8 | 0 | 63231 | gtex_brain_putamen_basal |
| rs12702091 | 7 | 44860763 | ZMIZ2 | ENSG00000122515.10 | 5.558E-7 | 0 | 72583 | gtex_brain_putamen_basal |
| rs10278679 | 7 | 44865064 | ZMIZ2 | ENSG00000122515.10 | 1.069E-6 | 0 | 76884 | gtex_brain_putamen_basal |
| rs13245012 | 7 | 44865719 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 77539 | gtex_brain_putamen_basal |
| rs2898 | 7 | 44866633 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 78453 | gtex_brain_putamen_basal |
| rs10267576 | 7 | 44870933 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 82753 | gtex_brain_putamen_basal |
| rs7789162 | 7 | 44872900 | ZMIZ2 | ENSG00000122515.10 | 2.519E-8 | 0 | 84720 | gtex_brain_putamen_basal |
| rs7805890 | 7 | 44872911 | ZMIZ2 | ENSG00000122515.10 | 3.152E-8 | 0 | 84731 | gtex_brain_putamen_basal |
| rs12155038 | 7 | 44872977 | ZMIZ2 | ENSG00000122515.10 | 7.897E-7 | 0 | 84797 | gtex_brain_putamen_basal |
| rs12536807 | 7 | 44878274 | ZMIZ2 | ENSG00000122515.10 | 2.517E-6 | 0 | 90094 | gtex_brain_putamen_basal |
| rs714543 | 7 | 44887076 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 98896 | gtex_brain_putamen_basal |
| rs757693 | 7 | 44888029 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 99849 | gtex_brain_putamen_basal |
| rs3757569 | 7 | 44889508 | ZMIZ2 | ENSG00000122515.10 | 1.08E-6 | 0 | 101328 | gtex_brain_putamen_basal |
| rs7783386 | 7 | 44893673 | ZMIZ2 | ENSG00000122515.10 | 1.07E-6 | 0 | 105493 | gtex_brain_putamen_basal |
| rs10951776 | 7 | 44897751 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 109571 | gtex_brain_putamen_basal |
| rs11762008 | 7 | 44903664 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 115484 | gtex_brain_putamen_basal |
| rs8840 | 7 | 44917040 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 128860 | gtex_brain_putamen_basal |
| rs1990053 | 7 | 44925896 | ZMIZ2 | ENSG00000122515.10 | 1.067E-6 | 0 | 137716 | gtex_brain_putamen_basal |
| rs2331174 | 7 | 44926827 | ZMIZ2 | ENSG00000122515.10 | 1.306E-6 | 0 | 138647 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZWINT | 0.79 | 0.61 |
| PTTG1 | 0.77 | 0.58 |
| CCNB1 | 0.77 | 0.59 |
| CDCA3 | 0.75 | 0.41 |
| CDT1 | 0.75 | 0.49 |
| TACC3 | 0.74 | 0.43 |
| SPC24 | 0.74 | 0.49 |
| CENPM | 0.74 | 0.45 |
| CENPA | 0.74 | 0.43 |
| UBE2C | 0.74 | 0.39 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.31 | -0.31 |
| AF347015.2 | -0.31 | -0.29 |
| AF347015.15 | -0.31 | -0.29 |
| AF347015.8 | -0.30 | -0.29 |
| MT-CO2 | -0.30 | -0.27 |
| MT-CYB | -0.30 | -0.28 |
| ABCG2 | -0.30 | -0.25 |
| AF347015.26 | -0.30 | -0.30 |
| AF347015.33 | -0.29 | -0.29 |
| SLC6A12 | -0.29 | -0.29 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID AR TF PATHWAY | 53 | 38 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN | 180 | 101 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE VIA P38 COMPLETE | 227 | 151 | All SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE NOT VIA P38 | 337 | 236 | All SZGR 2.0 genes in this pathway |