Gene Page: UXT

Summary ?
GeneID8409
SymbolUXT
SynonymsART-27|STAP1
Descriptionubiquitously expressed prefoldin like chaperone
ReferenceMIM:300234|HGNC:HGNC:12641|Ensembl:ENSG00000126756|HPRD:02209|Vega:OTTHUMG00000021453
Gene typeprotein-coding
Map locationXp11.23-p11.22
Sherlock p-value0.289
Fetal beta0.931

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC009163.10.730.54
C1orf1920.720.60
FBXL130.710.48
C20orf260.710.65
TMEM470.700.70
CRISPLD10.700.56
UBXN100.690.59
CCDC1030.690.54
IQCH0.690.50
MDFIC0.680.59
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.25-0.30
CXCL14-0.24-0.22
AF347015.2-0.23-0.25
AF347015.31-0.23-0.27
AP000679.1-0.23-0.29
AC098691.2-0.23-0.33
CSAG1-0.22-0.28
AF347015.21-0.22-0.28
PLA2G5-0.22-0.21
AF347015.8-0.22-0.26

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008017microtubule bindingTAS12762840 
GO:0051082unfolded protein bindingIEA-
GO:0051015actin filament bindingIDA12762840 
GO:0048487beta-tubulin bindingIDA12762840 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000226microtubule cytoskeleton organizationIMP16221885 
GO:0006457protein foldingIEA-
GO:0051297centrosome organizationIMP16221885 
GO:0047497mitochondrion transport along microtubuleTAS12762840 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000930gamma-tubulin complexIDA16221885 
GO:0005813centrosomeIDA16221885 
GO:0005856cytoskeletonIDA12762840 
GO:0005634nucleusIDA12762840 
GO:0005737cytoplasmIEA-
GO:0016272prefoldin complexIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11854421 
BUB3BUB3L | hBUB3budding uninhibited by benzimidazoles 3 homolog (yeast)Two-hybridBioGRID12762840 
C19orf2FLJ10575 | NNX3 | RMP | URIchromosome 19 open reading frame 2URI interacts with STAP1.BIND14615539 
CECR2KIAA1740cat eye syndrome chromosome region, candidate 2-HPRD,BioGRID12762840 
CITED2MRG1 | P35SRJCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Two-hybridBioGRID12762840 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1E2F1 interacts with the UXT chromatin.BIND11799066 
E2F2E2F-2E2F transcription factor 2E2F2 interacts with the UXT chromatin.BIND11799066 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3E2F3 interacts with the UXT chromatin.BIND11799066 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with the UXT chromatin.BIND11799066 
GLE1GLE1L | LCCS | LCCS1 | hGLE1GLE1 RNA export mediator homolog (yeast)Two-hybridBioGRID14645504 
LRPPRCCLONE-23970 | GP130 | LRP130 | LSFCleucine-rich PPR-motif containing-HPRD,BioGRID11827465 
LSM1CASM | YJL124CLSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID15231747 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)p107 interacts with the UXT chromatin.BIND11799066 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)p130 interacts with the UXT chromatin.BIND11799066 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)STAP1 interacts with SKP2.BIND14615539 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 7746All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193112All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 7253All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway