Gene Page: KAT8

Summary ?
GeneID84148
SymbolKAT8
SynonymsMOF|MYST1|ZC2HC8|hMOF
Descriptionlysine acetyltransferase 8
ReferenceMIM:609912|HGNC:HGNC:17933|Ensembl:ENSG00000103510|HPRD:11381|Vega:OTTHUMG00000132410
Gene typeprotein-coding
Map location16p11.2
Pascal p-value0.179
Sherlock p-value0.449
Fetal beta0.7
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0004402histone acetyltransferase activityIDA11742995 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008134transcription factor bindingIDA11742995 |11965546 
GO:0016407acetyltransferase activityIDA11742995 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006333chromatin assembly or disassemblyIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0030099myeloid cell differentiationIDA11742995 
GO:0016568chromatin modificationIEA-
GO:0016481negative regulation of transcriptionIDA11742995 
GO:0016573histone acetylationIDA11742995 
GO:0045941positive regulation of transcriptionIDA11742995 |11965546 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000776kinetochoreIEA-
GO:0000785chromatinIEA-
GO:0005634nucleusIDA11742995 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 7038All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 6637All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP 7456All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway