Gene Page: MRI1
Summary ?
| GeneID | 84245 |
| Symbol | MRI1 |
| Synonyms | MRDI|MTNA|Ypr118w |
| Description | methylthioribose-1-phosphate isomerase 1 |
| Reference | MIM:615105|HGNC:HGNC:28469|Ensembl:ENSG00000037757|HPRD:14548|Vega:OTTHUMG00000180867 |
| Gene type | protein-coding |
| Map location | 19p13.2 |
| Pascal p-value | 0.015 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs435207 | 19 | 13865275 | MRI1 | ENSG00000037757.9 | 9.066E-7 | 0 | -10071 | gtex_brain_ba24 |
| rs447668 | 19 | 13865276 | MRI1 | ENSG00000037757.9 | 8.967E-7 | 0 | -10070 | gtex_brain_ba24 |
| rs693151 | 19 | 13868117 | MRI1 | ENSG00000037757.9 | 1.126E-7 | 0 | -7229 | gtex_brain_ba24 |
| rs6511886 | 19 | 13868669 | MRI1 | ENSG00000037757.9 | 1.291E-6 | 0 | -6677 | gtex_brain_ba24 |
| rs6511887 | 19 | 13869251 | MRI1 | ENSG00000037757.9 | 2.138E-8 | 0 | -6095 | gtex_brain_ba24 |
| rs371671 | 19 | 13870153 | MRI1 | ENSG00000037757.9 | 1.27E-8 | 0 | -5193 | gtex_brain_ba24 |
| rs517323 | 19 | 13870227 | MRI1 | ENSG00000037757.9 | 1.326E-8 | 0 | -5119 | gtex_brain_ba24 |
| rs201996394 | 19 | 13871410 | MRI1 | ENSG00000037757.9 | 1.607E-9 | 0 | -3936 | gtex_brain_ba24 |
| rs452960 | 19 | 13871411 | MRI1 | ENSG00000037757.9 | 5.539E-9 | 0 | -3935 | gtex_brain_ba24 |
| rs375486 | 19 | 13871554 | MRI1 | ENSG00000037757.9 | 2.138E-8 | 0 | -3792 | gtex_brain_ba24 |
| rs404195 | 19 | 13871830 | MRI1 | ENSG00000037757.9 | 1.332E-8 | 0 | -3516 | gtex_brain_ba24 |
| rs73009852 | 19 | 13871858 | MRI1 | ENSG00000037757.9 | 5.506E-9 | 0 | -3488 | gtex_brain_ba24 |
| rs8109392 | 19 | 13872240 | MRI1 | ENSG00000037757.9 | 5.529E-9 | 0 | -3106 | gtex_brain_ba24 |
| rs151037434 | 19 | 13872531 | MRI1 | ENSG00000037757.9 | 5.015E-9 | 0 | -2815 | gtex_brain_ba24 |
| rs76498951 | 19 | 13872565 | MRI1 | ENSG00000037757.9 | 2.138E-8 | 0 | -2781 | gtex_brain_ba24 |
| rs74482708 | 19 | 13872597 | MRI1 | ENSG00000037757.9 | 7.694E-9 | 0 | -2749 | gtex_brain_ba24 |
| rs62111893 | 19 | 13874258 | MRI1 | ENSG00000037757.9 | 5.529E-9 | 0 | -1088 | gtex_brain_ba24 |
| rs62111894 | 19 | 13875162 | MRI1 | ENSG00000037757.9 | 5.13E-7 | 0 | -184 | gtex_brain_ba24 |
| rs62111895 | 19 | 13875186 | MRI1 | ENSG00000037757.9 | 3.017E-8 | 0 | -160 | gtex_brain_ba24 |
| rs62111896 | 19 | 13875210 | MRI1 | ENSG00000037757.9 | 9.662E-9 | 0 | -136 | gtex_brain_ba24 |
| rs443029 | 19 | 13875234 | MRI1 | ENSG00000037757.9 | 1.093E-8 | 0 | -112 | gtex_brain_ba24 |
| rs455093 | 19 | 13875258 | MRI1 | ENSG00000037757.9 | 1.115E-8 | 0 | -88 | gtex_brain_ba24 |
| rs2922288 | 19 | 13875626 | MRI1 | ENSG00000037757.9 | 3.223E-8 | 0 | 280 | gtex_brain_ba24 |
| rs6511886 | 19 | 13868669 | MRI1 | ENSG00000037757.9 | 2.361E-7 | 0.01 | -6677 | gtex_brain_putamen_basal |
| rs6511887 | 19 | 13869251 | MRI1 | ENSG00000037757.9 | 9.147E-7 | 0.01 | -6095 | gtex_brain_putamen_basal |
| rs201996394 | 19 | 13871410 | MRI1 | ENSG00000037757.9 | 5.535E-7 | 0.01 | -3936 | gtex_brain_putamen_basal |
| rs452960 | 19 | 13871411 | MRI1 | ENSG00000037757.9 | 1.161E-6 | 0.01 | -3935 | gtex_brain_putamen_basal |
| rs375486 | 19 | 13871554 | MRI1 | ENSG00000037757.9 | 5.833E-7 | 0.01 | -3792 | gtex_brain_putamen_basal |
| rs76498951 | 19 | 13872565 | MRI1 | ENSG00000037757.9 | 5.856E-7 | 0.01 | -2781 | gtex_brain_putamen_basal |
| rs62111895 | 19 | 13875186 | MRI1 | ENSG00000037757.9 | 1.558E-6 | 0.01 | -160 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME SULFUR AMINO ACID METABOLISM | 24 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 200 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF POLYAMINES | 15 | 11 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS UP | 126 | 84 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS | 212 | 121 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G1 S | 147 | 76 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |