Gene Page: PPFIA3
Summary ?
| GeneID | 8541 |
| Symbol | PPFIA3 |
| Synonyms | LPNA3 |
| Description | PTPRF interacting protein alpha 3 |
| Reference | MIM:603144|HGNC:HGNC:9247|Ensembl:ENSG00000177380|HPRD:04393|Vega:OTTHUMG00000183213 |
| Gene type | protein-coding |
| Map location | 19q13.33 |
| Pascal p-value | 0.02 |
| Sherlock p-value | 0.998 |
| eGene | Caudate basal ganglia Frontal Cortex BA9 |
| Support | PROTEIN CLUSTERING G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WSB1 | 0.68 | 0.52 |
| LENG8 | 0.66 | 0.54 |
| PILRB | 0.66 | 0.53 |
| CCDC84 | 0.65 | 0.48 |
| SEC31B | 0.64 | 0.52 |
| GOLGA8A | 0.64 | 0.52 |
| ZNF83 | 0.64 | 0.43 |
| STK36 | 0.63 | 0.49 |
| TRIM45 | 0.63 | 0.48 |
| ZMYND17 | 0.63 | 0.38 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TM4SF18 | -0.26 | -0.26 |
| CARD16 | -0.25 | -0.26 |
| GIMAP4 | -0.24 | -0.26 |
| C15orf24 | -0.24 | -0.25 |
| SEC62 | -0.24 | -0.25 |
| SNX3 | -0.23 | -0.23 |
| NDUFB5 | -0.23 | -0.30 |
| B2M | -0.23 | -0.23 |
| GMFG | -0.23 | -0.27 |
| KBTBD3 | -0.23 | -0.25 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ERC2 | CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110 | ELKS/RAB6-interacting/CAST family member 2 | Liprin-alpha3 interacts with ERC2. | BIND | 12923177 |
| ERC2 | CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110 | ELKS/RAB6-interacting/CAST family member 2 | - | HPRD,BioGRID | 12923177 |
| GIT1 | - | G protein-coupled receptor kinase interacting ArfGAP 1 | Reconstituted Complex Two-hybrid | BioGRID | 12923177 |
| GIT1 | - | G protein-coupled receptor kinase interacting ArfGAP 1 | Liprin-alpha3 interacts with GIT1. This interaction was modeled on a demonstrated interaction between human liprin-alpha3 and rat GIT1. | BIND | 12923177 |
| PPFIA1 | FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | - | HPRD,BioGRID | 9624153 |
| PPFIA2 | FLJ41378 | MGC132572 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 | - | HPRD,BioGRID | 9624153 |
| PPFIBP1 | L2 | hSGT2 | hSgt2p | PTPRF interacting protein, binding protein 1 (liprin beta 1) | - | HPRD,BioGRID | 9624153 |
| PPFIBP2 | Cclp1 | DKFZp781K06126 | MGC42541 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | - | HPRD,BioGRID | 9624153 |
| PPP2CA | PP2Ac | PP2CA | RP-C | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | Affinity Capture-MS | BioGRID | 18782753 |
| PTPRD | HPTP | HPTP-DELTA | HPTPD | MGC119750 | MGC119751 | MGC119752 | MGC119753 | PTPD | R-PTP-DELTA | protein tyrosine phosphatase, receptor type, D | - | HPRD,BioGRID | 9624153 |
| PTPRF | FLJ43335 | FLJ45062 | FLJ45567 | LAR | protein tyrosine phosphatase, receptor type, F | - | HPRD,BioGRID | 9624153 |
| PTPRS | PTPSIGMA | protein tyrosine phosphatase, receptor type, S | - | HPRD,BioGRID | 9624153 |
| PTPRU | FLJ37530 | FMI | GLEPP1 | PCP-2 | PTP | PTP-J | PTP-PI | PTPPSI | PTPRO | PTPU2 | R-PTP-PSI | hPTP-J | protein tyrosine phosphatase, receptor type, U | - | HPRD,BioGRID | 9624153 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KIM WT1 TARGETS 8HR DN | 129 | 84 | All SZGR 2.0 genes in this pathway |
| ZHANG TARGETS OF EWSR1 FLI1 FUSION | 88 | 68 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI UP | 92 | 58 | All SZGR 2.0 genes in this pathway |
| KIM GASTRIC CANCER CHEMOSENSITIVITY | 103 | 64 | All SZGR 2.0 genes in this pathway |
| FOSTER TOLERANT MACROPHAGE UP | 156 | 92 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |