Gene Page: EIF2B5

Summary ?
GeneID8893
SymbolEIF2B5
SynonymsCACH|CLE|EIF-2B|EIF2Bepsilon|LVWM
Descriptioneukaryotic translation initiation factor 2B subunit epsilon
ReferenceMIM:603945|HGNC:HGNC:3261|Ensembl:ENSG00000145191|HPRD:04898|Vega:OTTHUMG00000156840
Gene typeprotein-coding
Map location3q27.1
Pascal p-value0.276
Sherlock p-value0.855
Fetal beta0.133
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg257391373183851986EIF2B56.05E-6-0.3570.011DMG:Wockner_2014
cg183137023183853126EIF2B54.02E-8-0.0081.13E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA11323413 
GO:0005085guanyl-nucleotide exchange factor activityIMP15054402 
GO:0005085guanyl-nucleotide exchange factor activityISS-
GO:0003743translation initiation factor activityIDA16289705 
GO:0003743translation initiation factor activityNAS8688466 
GO:0005515protein bindingIPI15060152 
GO:0005515protein bindingISS-
GO:0016740transferase activityIEA-
GO:0008415acyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014003oligodendrocyte developmentIMPaxon, oligodendrocyte, Glial (GO term level: 10)15217090 
GO:0014002astrocyte developmentIMPneuron, astrocyte, Glial (GO term level: 10)15723074 
GO:0042552myelinationIMPneuron, axon, Brain, oligodendrocyte (GO term level: 13)14566705 |15723074 
GO:0001541ovarian follicle developmentIMP15507143 
GO:0009408response to heatIMP15723074 
GO:0009408response to heatISS-
GO:0009408response to heatTAS12499492 
GO:0009749response to glucose stimulusISS-
GO:0043434response to peptide hormone stimulusISS-
GO:0045948positive regulation of translational initiationISS-
GO:0051716cellular response to stimulusIDA8626696 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005851eukaryotic translation initiation factor 2B complexIDA11323413 |15060152 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA11323413 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA EIF2 PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY 2014All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY 2918All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
SLEBOS HEAD AND NECK CANCER WITH HPV UP 8443All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 14386All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-200bc/429136142m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU