Gene Page: MED30
Summary ?
| GeneID | 90390 |
| Symbol | MED30 |
| Synonyms | MED30S|THRAP6|TRAP25 |
| Description | mediator complex subunit 30 |
| Reference | MIM:610237|HGNC:HGNC:23032|Ensembl:ENSG00000164758|HPRD:11631|Vega:OTTHUMG00000164920 |
| Gene type | protein-coding |
| Map location | 8q24.11 |
| Pascal p-value | 4.914E-4 |
| Sherlock p-value | 0.433 |
| eGene | Frontal Cortex BA9 Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| REEP1 | 0.88 | 0.94 |
| PRKAB2 | 0.86 | 0.91 |
| PANX1 | 0.86 | 0.95 |
| CSRNP3 | 0.86 | 0.91 |
| KBTBD6 | 0.85 | 0.94 |
| GNG2 | 0.85 | 0.92 |
| ST8SIA4 | 0.84 | 0.92 |
| NLN | 0.84 | 0.94 |
| CXADR | 0.84 | 0.92 |
| AP2B1 | 0.83 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HEPN1 | -0.59 | -0.75 |
| TSC22D4 | -0.58 | -0.77 |
| HLA-F | -0.58 | -0.74 |
| FXYD1 | -0.57 | -0.84 |
| AF347015.31 | -0.57 | -0.83 |
| C5orf53 | -0.57 | -0.71 |
| MT-CO2 | -0.56 | -0.85 |
| AF347015.33 | -0.56 | -0.81 |
| S100B | -0.56 | -0.80 |
| AIFM3 | -0.56 | -0.72 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| MED10 | L6 | MGC5309 | NUT2 | TRG20 | mediator complex subunit 10 | Affinity Capture-MS | BioGRID | 15175163 |
| MED17 | CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80 | mediator complex subunit 17 | TRAP80 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human TRAP80 and mouse TRAP25. | BIND | 12584197 |
| MED19 | DT2P1G7 | LCMR1 | mediator complex subunit 19 | Affinity Capture-MS | BioGRID | 15175163 |
| MED21 | SRB7 | SURB7 | mediator complex subunit 21 | Reconstituted Complex | BioGRID | 12584197 |
| MED22 | MED24 | MGC48682 | SURF5 | mediator complex subunit 22 | - | HPRD,BioGRID | 12584197 |
| MED22 | MED24 | MGC48682 | SURF5 | mediator complex subunit 22 | Surf5 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human Surf5 and mouse TRAP25. | BIND | 12584197 |
| MED26 | CRSP7 | CRSP70 | mediator complex subunit 26 | Affinity Capture-MS | BioGRID | 15175163 |
| MED27 | CRAP34 | CRSP34 | CRSP8 | MGC11274 | TRAP37 | mediator complex subunit 27 | TRAP37 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human TRAP37 and mouse TRAP25. | BIND | 12584197 |
| MED27 | CRAP34 | CRSP34 | CRSP8 | MGC11274 | TRAP37 | mediator complex subunit 27 | Reconstituted Complex | BioGRID | 12584197 |
| MED28 | 1500003D12Rik | DKFZp434N185 | EG1 | magicin | mediator complex subunit 28 | Affinity Capture-MS | BioGRID | 15175163 |
| MED28 | 1500003D12Rik | DKFZp434N185 | EG1 | magicin | mediator complex subunit 28 | - | HPRD | 11591653 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | - | HPRD | 14576168 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | Affinity Capture-MS | BioGRID | 15175163 |
| MED4 | DRIP36 | FLJ10956 | HSPC126 | RP11-90M2.2 | TRAP36 | VDRIP | mediator complex subunit 4 | TRAP36 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human TRAP36 and mouse TRAP25. | BIND | 12584197 |
| MED4 | DRIP36 | FLJ10956 | HSPC126 | RP11-90M2.2 | TRAP36 | VDRIP | mediator complex subunit 4 | Reconstituted Complex | BioGRID | 12584197 |
| MED6 | NY-REN-28 | mediator complex subunit 6 | Reconstituted Complex | BioGRID | 12584197 |
| MED8 | ARC32 | MGC17544 | MGC19641 | mediator complex subunit 8 | Reconstituted Complex | BioGRID | 12584197 |
| MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | Affinity Capture-MS | BioGRID | 15175163 |
| MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | - | HPRD | 14638676 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON | 157 | 87 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | 58 | 25 | All SZGR 2.0 genes in this pathway |