Gene Page: P2RX6

Summary ?
GeneID9127
SymbolP2RX6
SynonymsP2RXL1|P2X6|P2XM
Descriptionpurinergic receptor P2X 6
ReferenceMIM:608077|HGNC:HGNC:8538|HPRD:08490|
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.334
DMG1 (# studies)
eGeneCortex
Meta
SupportGPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg010381492221368765P2RX61.36E-10-0.014.9E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ALK0.790.70
ABLIM30.790.77
ATBF10.750.69
PEG100.740.73
AC008522.10.740.74
IGSF9B0.740.75
CDR20.740.83
RGMB0.730.74
KIAA10240.730.81
BLCAP0.730.72
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.50-0.62
MT-CO2-0.48-0.60
AF347015.21-0.48-0.63
COPZ2-0.46-0.55
HIGD1B-0.46-0.58
AF347015.33-0.45-0.53
MT-CYB-0.45-0.55
AF347015.8-0.45-0.57
AF347015.2-0.45-0.53
LGALS3-0.43-0.60

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001614purinergic nucleotide receptor activityNAS12088286 
GO:0004888transmembrane receptor activityTAS9242461 
GO:0004872receptor activityIEA-
GO:0004931ATP-gated cation channel activityNAS12088286 
GO:0005524ATP bindingIEA-
GO:0005216ion channel activityIEA-
GO:0015267channel activityTAS9242461 
GO:0046982protein heterodimerization activityNAS17895406 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9242461 
GO:0006811ion transportIEA-
GO:0006936muscle contractionTAS9242461 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA12088286 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneTAS9242461 
GO:0030054cell junctionIDA12088286 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238135All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 3524All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 8959All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 8148All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 12868All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 4527All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway