Gene Page: ZW10

Summary ?
GeneID9183
SymbolZW10
SynonymsHZW10|KNTC1AP
Descriptionzw10 kinetochore protein
ReferenceMIM:603954|HGNC:HGNC:13194|Ensembl:ENSG00000086827|HPRD:04902|Vega:OTTHUMG00000168190
Gene typeprotein-coding
Map location11q23.2
Pascal p-value0.221
Sherlock p-value0.248
Fetal beta0.197
DMG1 (# studies)
eGeneNucleus accumbens basal ganglia
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IGenome scan meta-analysisPsr: 0.006 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0029583511113644563ZW106.98E-9-0.0123.55E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LRMP0.620.65
KLK70.550.54
C13orf360.540.64
CCDC28A0.520.54
POPDC30.520.63
HPRT10.510.54
AC090772.40.500.51
MAPK30.490.54
AC008670.20.490.35
TSPAN160.490.32
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HYAL2-0.38-0.48
TBC1D16-0.38-0.43
TES-0.38-0.50
SMTN-0.37-0.46
SH3BP2-0.36-0.51
GLIS2-0.36-0.44
CBX8-0.36-0.35
FLT4-0.36-0.42
SBNO2-0.36-0.42
LRP5-0.36-0.45

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11146660 |12686595 
GO:0019237centromeric DNA bindingTAS9700164 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000070mitotic sister chromatid segregationIDA11146660 
GO:0006461protein complex assemblyIDA11146660 
GO:0007049cell cycleIEA-
GO:0007093mitotic cell cycle checkpointIDA11146660 
GO:0007096regulation of exit from mitosisIDA11146660 
GO:0007126meiosisTAS9298984 
GO:0006888ER to Golgi vesicle-mediated transportIMP15029241 
GO:0016192vesicle-mediated transportIEA-
GO:0015031protein transportIEA-
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000777condensed chromosome kinetochoreIEA-
GO:0000922spindle poleIDA11146660 
GO:0005828kinetochore microtubuleIDA11146660 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusIDA15485811 
GO:0005737cytoplasmIEA-
GO:0005783endoplasmic reticulumIDA15029241 
GO:0016020membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 8751All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165106All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM DN 5734All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway