SZGR2

Summary ?

GeneID	925
Symbol	CD8A
Synonyms	CD8\|Leu2\|MAL\|p32
Description	CD8a molecule
Reference	MIM:186910\|HGNC:HGNC:1706\|Ensembl:ENSG00000153563\|HPRD:01737\|Vega:OTTHUMG00000130265
Gene type	protein-coding
Map location	2p12
Pascal p-value	0.004
Fetal beta	-0.25
DMG	2 (# studies)
eGene	Cerebellum Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	3
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	3
GSMA_I	Genome scan meta-analysis	Psr: 0.0004
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg03318654	2	87034200	CD8A	2.408E-4	0.45	0.037	DMG:Wockner_2014
cg02870945	2	86565124	CD8A	6.249E-4	11.142		DMG:vanEijk_2014
cg02870945	2	86565124	CD8A	0.003	10.047		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MMP25	0.61	0.56
KCTD11	0.57	0.56
DPEP1	0.57	0.54
NT5DC2	0.57	0.54
AC006273.1	0.56	0.51
ISYNA1	0.56	0.55
COMTD1	0.56	0.47
PPDPF	0.56	0.46
PVRL2	0.56	0.51
RAC3	0.56	0.46

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ALDOC	-0.43	-0.45
RGN	-0.42	-0.47
FBXO2	-0.42	-0.44
OMG	-0.41	-0.48
C5orf53	-0.41	-0.48
CSRP1	-0.41	-0.45
CCNI2	-0.40	-0.44
SPARCL1	-0.40	-0.44
CA2	-0.39	-0.47
ANXA11	-0.39	-0.44

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		2470098 \|2493728
GO:0042288	MHC class I protein binding	NAS		11131152
GO:0015026	coreceptor activity	NAS		11131152
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0002456	T cell mediated immunity	IEA		-
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS		9830036
GO:0007166	cell surface receptor linked signal transduction	IEA		-
GO:0019882	antigen processing and presentation	NAS		2496167
GO:0006955	immune response	NAS		11131152
GO:0042110	T cell activation	NAS		9830036
GO:0050850	positive regulation of calcium-mediated signaling	IEA		-
GO:0045065	cytotoxic T cell differentiation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0042101	T cell receptor complex	NAS	Synap (GO term level: 8)	11131152
GO:0005576	extracellular region	IEA		-
GO:0009897	external side of plasma membrane	IEA		-
GO:0005886	plasma membrane	IEA		-
GO:0005887	integral to plasma membrane	NAS		2496167

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CD3D	CD3-DELTA \| T3D	CD3d molecule, delta (CD3-TCR complex)	-	HPRD,BioGRID	12215456
CD59	16.3A5 \| 1F5 \| EJ16 \| EJ30 \| EL32 \| FLJ38134 \| FLJ92039 \| G344 \| HRF-20 \| HRF20 \| MAC-IP \| MACIF \| MEM43 \| MGC2354 \| MIC11 \| MIN1 \| MIN2 \| MIN3 \| MIRL \| MSK21 \| p18-20	CD59 molecule, complement regulatory protein	Reconstituted Complex	BioGRID	1377690
CD8A	CD8 \| Leu2 \| MAL \| p32	CD8a molecule	Co-crystal Structure Co-localization	BioGRID	8127870 \|9550407
CD8A	CD8 \| Leu2 \| MAL \| p32	CD8a molecule	-	HPRD	8127870 \|10809759
CD8B	CD8B1 \| LYT3 \| Leu2 \| Ly3 \| MGC119115	CD8b molecule	-	HPRD,BioGRID	3145195 \|9550407 \|10623829\|10809759
HLA-A	HLAA	major histocompatibility complex, class I, A	-	HPRD,BioGRID	9177355 \|10809759\|10809759
HLA-B	AS \| HLA-B-7301 \| HLA-B73 \| HLAB \| HLAC \| SPDA1	major histocompatibility complex, class I, B	-	HPRD,BioGRID	9331948 \|10809759\|10809759
HLA-C	D6S204 \| FLJ27082 \| HLA-Cw \| HLA-Cw12 \| HLA-JY3 \| HLC-C \| PSORS1	major histocompatibility complex, class I, C	-	HPRD,BioGRID	10809759
HLA-E	DKFZp686P19218 \| EA1.2 \| EA2.1 \| HLA-6.2 \| MHC \| QA1	major histocompatibility complex, class I, E	-	HPRD	10809759
HLA-G	MHC-G	major histocompatibility complex, class I, G	-	HPRD	1908512 \|10843658\|10809759
HLA-G	MHC-G	major histocompatibility complex, class I, G	in vivo Reconstituted Complex	BioGRID	1908512 \|10809759 \|10843658
LAT	LAT1 \| pp36	linker for activation of T cells	-	HPRD	10562325
LGALS1	DKFZp686E23103 \| GAL1 \| GBP	lectin, galactoside-binding, soluble, 1	-	HPRD,BioGRID	10490978
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD,BioGRID	1834739
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL ADHESION MOLECULES CAMS	134	93	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE	88	60	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG PRIMARY IMMUNODEFICIENCY	35	28	All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY	17	12	All SZGR 2.0 genes in this pathway
BIOCARTA STEM PATHWAY	15	13	All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	70	37	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP	177	110	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP	116	68	All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA	103	58	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1	44	23	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP	35	25	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION	81	59	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
LEE DOUBLE POLAR THYMOCYTE	27	17	All SZGR 2.0 genes in this pathway
FINAK BREAST CANCER SDPP SIGNATURE	26	11	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
CHIARETTI T ALL RELAPSE PROGNOSIS	19	15	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-186	151	157	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CD8A