SZGR2

Summary ?

GeneID	93
Symbol	ACVR2B
Synonyms	ACTRIIB\|ActR-IIB\|HTX4
Description	activin A receptor type 2B
Reference	MIM:602730\|HGNC:HGNC:174\|Ensembl:ENSG00000114739\|HPRD:04106\|Vega:OTTHUMG00000131291
Gene type	protein-coding
Map location	3p22
Pascal p-value	2.88E-4
Sherlock p-value	0.461
eGene	Cerebellar Hemisphere Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.006

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16829545	chr2	151977407	ACVR2B	93	0.04	trans
rs10473751		0	ACVR2B	93	0.17	trans
rs16955618	chr15	29937543	ACVR2B	93	0.18	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0004872	receptor activity	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0019838	growth factor binding	IPI		14517293
GO:0016362	activin receptor activity, type II	TAS		8622651
GO:0030145	manganese ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0009952	anterior/posterior pattern formation	IMP		9916847
GO:0007165	signal transduction	IDA		8622651
GO:0030501	positive regulation of bone mineralization	IMP		18436533
GO:0030509	BMP signaling pathway	EXP		15621726
GO:0030509	BMP signaling pathway	IDA		18436533
GO:0032927	positive regulation of activin receptor signaling pathway	IDA		8622651
GO:0045669	positive regulation of osteoblast differentiation	IMP		18436533
GO:0045449	regulation of transcription	IDA		8622651
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IDA		14738881
GO:0009986	cell surface	IDA		12493773
GO:0005886	plasma membrane	EXP		17356069
GO:0005887	integral to plasma membrane	TAS		8161782

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	activin A receptor, type IB	-	HPRD	8612709\|8622651
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	activin A receptor, type IB	-	HPRD,BioGRID	8612709
BMP6	VGR \| VGR1	bone morphogenetic protein 6	Affinity Capture-Western	BioGRID	10504300
BMP7	OP-1	bone morphogenetic protein 7	-	HPRD,BioGRID	9748228
ENG	CD105 \| END \| FLJ41744 \| HHT1 \| ORW \| ORW1	endoglin	Affinity Capture-Western	BioGRID	9872992
GDF11	BMP-11 \| BMP11	growth differentiation factor 11	-	HPRD,BioGRID	10391213
GDF5	BMP14 \| CDMP1 \| LAP4 \| SYNS2	growth differentiation factor 5	-	HPRD,BioGRID	8702914
IGSF1	IGCD1 \| IGDC1 \| INHBP \| KIAA0364 \| MGC75490 \| PGSF2	immunoglobulin superfamily, member 1	-	HPRD	11266516
INHBA	EDF \| FRP	inhibin, beta A	-	HPRD,BioGRID	9202237
INHBB	MGC157939	inhibin, beta B	-	HPRD,BioGRID	9202237
INHBC	IHBC	inhibin, beta C	-	HPRD	12651901
MSTN	GDF8	myostatin	-	HPRD,BioGRID	11459935
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	sorting nexin 1	-	HPRD,BioGRID	11279102
SNX2	MGC5204 \| TRG-9	sorting nexin 2	Affinity Capture-Western	BioGRID	11279102
SNX6	MGC3157 \| MSTP010 \| TFAF2	sorting nexin 6	-	HPRD,BioGRID	11279102
SYNJ2BP	ARIP2 \| FLJ11271 \| FLJ41973 \| OMP25	synaptojanin 2 binding protein	-	HPRD,BioGRID	11882656 \|15451561
TGFBRAP1	TRAP-1 \| TRAP1	transforming growth factor, beta receptor associated protein 1	-	HPRD	11278302

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NODAL	18	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP	23	15	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN	139	76	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3	48	31	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN	65	45	All SZGR 2.0 genes in this pathway
SU PLACENTA	30	18	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN	116	83	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
RAFFEL VEGFA TARGETS UP	9	8	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1456	1462	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-101	214	220	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	402	409	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	402	409	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124/506	7202	7208	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	7202	7208	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-132/212	435	442	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	435	442	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-138	199	205	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-144	214	220	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-148/152	9664	9670	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497	109	115	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-181	9691	9698	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-183	2491	2498	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-186	2458	2464	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-194	437	444	1A,m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-199	675	682	1A,m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	675	682	1A,m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	7589	7595	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	7676	7682	m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-214	8016	8022	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-221/222	2577	2584	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	2577	2584	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	9688	9694	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	9688	9694	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	5893	5899	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	5893	5899	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-320	2468	2474	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-320	2468	2474	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-324-5p	7318	7324	1A	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU
miR-346	9493	9499	1A	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-369-3p	150	156	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	150	156	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-370	240	246	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-374	150	157	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-374	150	157	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	6288	6294	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-377	9711	9718	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	8998	9005	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	8998	9005	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-384	391	397	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-410	1488	1494	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-410	1488	1494	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-485-5p	293	299	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-503	109	115	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-539	8204	8210	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-9	7654	7660	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ACVR2B