Gene Page: ARHGEF11

Summary
GeneID  9826
Symbol  ARHGEF11
Synonyms  DKFZp667F1223|GTRAP48|KIAA0380|PDZ-RHOGEF
Description  Rho guanine nucleotide exchange factor (GEF) 11
See related  HGNC:14580|MIM:605708|Ensembl:ENSG00000132694|HPRD:09302|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SNAP470.860.81
TMEM55B0.850.80
TOMM40L0.840.79
ATG4B0.840.80
ARFIP20.840.74
UBL4A0.830.78
ST3GAL30.830.81
C7orf200.820.78
TBRG40.820.76
GSK3A0.820.77
Top 10 negatively co-expressed genes
AF347015.21-0.71-0.64
AF347015.8-0.70-0.60
MT-CO2-0.68-0.58
AF347015.18-0.67-0.63
AF347015.26-0.67-0.58
MT-CYB-0.67-0.59
AF347015.2-0.67-0.57
AF347015.31-0.67-0.58
MT-ATP8-0.66-0.64
AF347015.27-0.66-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005089Rho guanyl-nucleotide exchange factor activityTAS10026210 
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0001664G-protein-coupled receptor bindingIDA15755723 
GO:0004871signal transducer activityIEA-
GO:0005096GTPase activator activityIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI10026210 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthNAS10026210 
GO:0000910cytokinesisNAS10026210 
GO:0007186G-protein coupled receptor protein signaling pathwayTAS10026210 
GO:0030010establishment of cell polarityNAS10026210 
GO:0006941striated muscle contractionNAS10026210 
GO:0006928cell motionNAS10026210 
GO:0030036actin cytoskeleton organizationNAS10026210 
GO:0035023regulation of Rho protein signal transductionIEA-
GO:0045893positive regulation of transcription, DNA-dependentIDA10026210 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIC10026210 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIDA15755723 
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12-HPRD,BioGRID10026210 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13-HPRD,BioGRID10026210 
PLXNB1KIAA0407 | MGC149167 | PLEXIN-B1 | PLXN5 | SEPplexin B1-HPRD,BioGRID12183458 
PLXNB2KIAA0315 | MM1 | Nbla00445 | PLEXB2 | dJ402G11.3plexin B2Affinity Capture-Western
Two-hybrid		BioGRID12123608 |12183458 
PLXNB3FLJ76953 | PLEXB3 | PLEXR | PLXN6plexin B3-HPRD,BioGRID12183458 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD,BioGRID10526156 
SLC1A6EAAT4 | MGC33092 | MGC43671solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6-HPRD11242047 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
PID_RHOA_REG_PATHWAY 4630All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3 12868All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
MIKKELSEN_NPC_LCP_WITH_H3K4ME3 5834All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1289951001m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-132/21210701076m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-17-5p/20/93.mr/106/519.d374380m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.