Gene Page: RUSC2
Summary ?
GeneID | 9853 |
Symbol | RUSC2 |
Synonyms | Iporin |
Description | RUN and SH3 domain containing 2 |
Reference | MIM:611053|HGNC:HGNC:23625|Ensembl:ENSG00000198853|HPRD:18009|Vega:OTTHUMG00000019861 |
Gene type | protein-coding |
Map location | 9p13.3 |
Pascal p-value | 0.013 |
Sherlock p-value | 0.58 |
Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MRPL38 | 0.89 | 0.88 |
ARF5 | 0.89 | 0.88 |
MRPL4 | 0.89 | 0.87 |
BTBD6 | 0.89 | 0.90 |
PSMG3 | 0.87 | 0.86 |
GEMIN7 | 0.86 | 0.84 |
C16orf84 | 0.86 | 0.86 |
AC019171.2 | 0.86 | 0.84 |
C19orf62 | 0.86 | 0.85 |
C19orf25 | 0.85 | 0.83 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.26 | -0.57 | -0.51 |
AF347015.18 | -0.57 | -0.54 |
MT-ATP8 | -0.56 | -0.53 |
AF347015.8 | -0.56 | -0.48 |
AF347015.15 | -0.54 | -0.46 |
AF347015.2 | -0.53 | -0.46 |
MT-CYB | -0.52 | -0.46 |
AF347015.27 | -0.51 | -0.47 |
AF347015.33 | -0.51 | -0.45 |
MT-CO2 | -0.50 | -0.42 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP | 207 | 128 | All SZGR 2.0 genes in this pathway |
GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | All SZGR 2.0 genes in this pathway |
MARCHINI TRABECTEDIN RESISTANCE DN | 49 | 34 | All SZGR 2.0 genes in this pathway |
DURCHDEWALD SKIN CARCINOGENESIS DN | 264 | 168 | All SZGR 2.0 genes in this pathway |
MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |