SZGR2

Summary ?

GeneID	23284
Symbol	ADGRL3
Synonyms	CIRL3\|CL3\|LEC3\|LPHN3
Description	adhesion G protein-coupled receptor L3
Reference	MIM:616417\|HGNC:HGNC:20974\|Ensembl:ENSG00000150471\|HPRD:10055\|Vega:OTTHUMG00000160690
Gene type	protein-coding
Map location	4q13.1

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC010522.1	0.60	0.50
RP11-274B21.1	0.58	0.55
AC018638.5	0.57	0.59
PVRIG	0.56	0.58
WNT7B	0.56	0.47
C19orf71	0.55	0.56
ZNF750	0.55	0.49
EPB41L4A	0.55	0.34
CRIPAK	0.55	0.57
CCDC57	0.55	0.55

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SNX3	-0.42	-0.49
KBTBD3	-0.40	-0.51
CISD1	-0.40	-0.47
NDUFB5	-0.39	-0.54
CACYBP	-0.39	-0.48
CALM2	-0.39	-0.46
PHYH	-0.39	-0.37
HIGD1A	-0.39	-0.44
XRCC6BP1	-0.38	-0.40
RHEB	-0.38	-0.44

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0005529	sugar binding	IEA		-
GO:0004930	G-protein coupled receptor activity	NAS		10994649
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007218	neuropeptide signaling pathway	IEA	Neurotransmitter (GO term level: 8)	-
GO:0007165	signal transduction	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016021	integral to membrane	NAS		10994649
GO:0005886	plasma membrane	IEA		-

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	1139	1146	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1139	1146	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	1686	1692	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	1980	1986	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-134	440	446	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-138	347	353	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
				hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
				hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-142-5p	1640	1647	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d	1639	1645	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	582	588	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-192/215	900	906	m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
				hsa-miR-215	AUGACCUAUGAAUUGACAGAC
				hsa-miR-192	CUGACCUAUGAAUUGACAGCC
				hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-216	2261	2267	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-30-5p	565	571	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-329	821	827	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-331	909	916	1A,m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-363	50	56	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-376c	1387	1394	1A,m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-379	1519	1526	1A,m8	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-450	1614	1620	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-455	2143	2149	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-493-5p	1395	1401	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-544	1364	1370	1A	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-96	582	588	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.