Gene Page: MRVI1
Summary ?
GeneID | 10335 |
Symbol | MRVI1 |
Synonyms | IRAG|JAW1L |
Description | murine retrovirus integration site 1 homolog |
Reference | MIM:604673|HGNC:HGNC:7237|Ensembl:ENSG00000072952|HPRD:05242|Vega:OTTHUMG00000165773 |
Gene type | protein-coding |
Map location | 11p15 |
Pascal p-value | 0.575 |
Sherlock p-value | 0.872 |
Fetal beta | -0.588 |
eGene | Myers' cis & trans Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWAScat | Genome-wide Association Studies | This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb. | |
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs10840431 | chr11 | 10524605 | MRVI1 | 10335 | 4.325E-6 | cis | ||
rs10770123 | chr11 | 10534865 | MRVI1 | 10335 | 0.08 | cis | ||
rs10840433 | chr11 | 10547173 | MRVI1 | 10335 | 0.16 | cis | ||
rs1350991 | chr11 | 10554629 | MRVI1 | 10335 | 0.19 | cis | ||
rs2054392 | chr11 | 10558598 | MRVI1 | 10335 | 4.089E-6 | cis | ||
rs10840444 | chr11 | 10624214 | MRVI1 | 10335 | 0.12 | cis | ||
rs964426 | chr11 | 10632251 | MRVI1 | 10335 | 4.205E-5 | cis | ||
rs964425 | chr11 | 10632483 | MRVI1 | 10335 | 1.253E-4 | cis | ||
rs10840431 | chr11 | 10524605 | MRVI1 | 10335 | 7.415E-4 | trans | ||
rs2054392 | chr11 | 10558598 | MRVI1 | 10335 | 7.061E-4 | trans | ||
rs964426 | chr11 | 10632251 | MRVI1 | 10335 | 0.01 | trans | ||
rs964425 | chr11 | 10632483 | MRVI1 | 10335 | 0.01 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SMPD4 | 0.94 | 0.94 |
CREBL1 | 0.94 | 0.93 |
ZNF384 | 0.94 | 0.94 |
CNOT3 | 0.94 | 0.93 |
CIZ1 | 0.94 | 0.94 |
DHX16 | 0.93 | 0.93 |
PPIL2 | 0.93 | 0.93 |
NFRKB | 0.93 | 0.93 |
DNMT1 | 0.92 | 0.92 |
GTF3C2 | 0.92 | 0.91 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.77 | -0.84 |
AF347015.27 | -0.75 | -0.82 |
MT-CO2 | -0.75 | -0.82 |
AF347015.21 | -0.72 | -0.89 |
MT-CYB | -0.72 | -0.79 |
AF347015.8 | -0.72 | -0.81 |
AF347015.33 | -0.71 | -0.77 |
IFI27 | -0.70 | -0.77 |
HIGD1B | -0.69 | -0.78 |
C5orf53 | -0.68 | -0.69 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION | 115 | 81 | All SZGR 2.0 genes in this pathway |
REACTOME CGMP EFFECTS | 19 | 13 | All SZGR 2.0 genes in this pathway |
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | 25 | 19 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET HOMEOSTASIS | 78 | 49 | All SZGR 2.0 genes in this pathway |
REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
CHEN NEUROBLASTOMA COPY NUMBER GAINS | 50 | 35 | All SZGR 2.0 genes in this pathway |
AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
IZADPANAH STEM CELL ADIPOSE VS BONE DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
NIELSEN GIST | 98 | 66 | All SZGR 2.0 genes in this pathway |
MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP | 134 | 85 | All SZGR 2.0 genes in this pathway |
PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
HUANG GATA2 TARGETS DN | 72 | 52 | All SZGR 2.0 genes in this pathway |
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP | 54 | 38 | All SZGR 2.0 genes in this pathway |
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |
LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |