| 1 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008 Apr 147: 351-5 |
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| PMID | 17948900 |
| Title | Is MYO9B the missing link between schizophrenia and celiac disease? |
| Abstract | There has long been discussion on the correlation between schizophrenia and autoimmune diseases (especially celiac disease), which makes the recently discovered celiac disease risk factor, MYO9B, an attractive functional and positional candidate gene for schizophrenia. To test this hypothesis we compared allele frequencies of three MYO9B tag SNPs in 315 schizophrenia cases and 1,624 healthy controls in a genetic association study. Highly significant differences in allele frequencies between schizophrenia cases and healthy controls were observed for SNP rs2305767 in intron 14 of MYO9B (P = 1.16 x 10(-4); OR 1.41, 95% CI 1.18-1.67). We demonstrate significant association of allelic variants in MYO9B with schizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developing schizophrenia. |
| SCZ Keywords | schizophrenia |
| 2 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011 Sep 156B: 709-19 |
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| PMID | 21688385 |
| Title | No association observed between schizophrenia and non-HLA coeliac disease genes: integration with the initial MYO9B association with coeliac disease. |
| Abstract | schizophrenia is a severe psychotic illness with a heterogeneous presentation and a devastating impact on social and occupational function. Worldwide variations in schizophrenia incidence rates suggest that local conditions may modify disease risk. The human leukocyte antigen (HLA) region has been confirmed to be associated with schizophrenia by genome-wide association studies in populations across the world. While the presence of autoimmune processes in a subgroup of schizophrenia cases is contentious, the immune system could allow environmental exposures to lead to schizophrenia by generating improper immune response. To investigate this topic, we reviewed the current evidence of the relationship between schizophrenia and coeliac disease. Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls. Finding no evidence for association with these two loci in our study samples, we applied meta-analytic techniques to combine our findings with previous reports. This synthesis, in light of our review of previous reports, suggests a differing developmental trajectory for schizophrenia and coeliac disease. It is possible that these two conditions do not share any functional overlap. |
| SCZ Keywords | schizophrenia |
| 3 | Psychiatr. Genet. 2015 Apr 25: 97 |
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| PMID | 25710847 |
| Title | Lack of genetic association between the MYO9B locus and schizophrenia in a Chinese population. |
| Abstract | Jungerius et al. (2008) have reported that the myosin IXB (MYO9B) gene is strongly associated with susceptibility to schizophrenia in a Dutch population. However, this initial work failed to be replicated in a British population (Law et al., 2011). The present study was then undertaken to examine whether the association of MYO9B with schizophrenia could be replicated in a Chinese population. |
| SCZ Keywords | schizophrenia |