| 1 | J. Hum. Genet. 2007 -1 52: 498-501 |
|---|
| PMID | 17427027 |
| Title | Gap junction coding genes and schizophrenia: a genetic association study. |
| Abstract | The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (PANX2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of PANX2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that PANX2 or Cx36 could increase the risk of schizophrenia in the Japanese population. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | J. Hum. Genet. 2007 -1 52: 498-501 |
|---|
| PMID | 17427027 |
| Title | Gap junction coding genes and schizophrenia: a genetic association study. |
| Abstract | The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (PANX2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of PANX2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that PANX2 or Cx36 could increase the risk of schizophrenia in the Japanese population. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 3 | Eur Arch Psychiatry Clin Neurosci 2015 Jul -1: -1 |
|---|
| PMID | 26223428 |
| Title | The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes. |
| Abstract | Pannexins are a group of brain-expressed channel proteins thought to be regulators of schizophrenia-linked pathways including glutamate release, synaptic plasticity and neural stem proliferation. We got evidence for linkage of a catatonic phenotype to the PANX2 locus in a family study. Aim of our study was to evaluate the role of Pannexins in schizophrenia and clinical phenotypes, particularly with regard to periodic catatonia. We genotyped six single-nucleotide polymorphisms at PANX1, five at PANX2 and three at PANX3 in 1173 German cases with schizophrenia according to DSM-5 and 480 controls. Our sample included 338 cases with periodic catatonia corresponding to Leonhard's classification. Association with schizophrenia according to DSM-5 was limited to genotype rs4838858-TT [p = 0.02, odds ratio (OR) 3.1] and haplotype rs4838858T-rs5771206G (p = 0.02, OR 2.7) at PANX2. We found no significant association with clinical phenotypes. Our limited findings do not support a major contribution of PANX1-3 to disease risk of schizophrenia according to DSM-5. We cannot confirm an association of the PANX2 loci at chromosome 22q13 with periodic catatonia. |
| SCZ Keywords | schizophrenia, schizophrenic |