| 1 | Am. J. Med. Genet. 2000 -1 97: 12-7 |
|---|---|
| PMID | 10813800 |
| Title | Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. |
| Abstract | Twin studies have been vital for establishing an important genetic contribution to the etiology of schizophrenia. The five newest studies since 1995 from Europe and Japan have confirmed earlier findings. They yielded probandwise concordance rates of 41-65% in monozygotic (MZ) pairs and 0-28% in dizygotic (DZ) pairs, and heritability estimates of approximately 80-85%. Twin studies are also valuable for investigating the etiological relationships between schizophrenia and other disorders, and the genetic basis of clinical heterogeneity within schizophrenia. Studies of discordant MZ pairs provide further insights into non-inherited factors that contribute to the multifactorial etiology of this disorder. More recently, twin studies have begun to be used to directly investigate molecular genetic and epigenetic processes underlying schizophrenia. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |
| 2 | Med. Hypotheses 2002 Oct 59: 416-21 |
| PMID | 12208181 |
| Title | Did schizophrenia change the course of English history? The mental illness of Henry VI. |
| Abstract | Henry VI, King of England, at age 19 founded Eton College and King's College, Cambridge. At 31 he had a sudden, dramatic mental illness in which he was mute and unresponsive. Before, he had been paranoid, grandiose, and indecisive. After, he was apathetic with deterioration of ability, drive, interest and self-care, and hallucinations and religious delusions. This illness, which is consistent with a diagnosis of schizophrenia, robbed Henry of his personality, his crown, his wife, his only son, and his life. It led to three decades of brutal fighting for the crown (the 'WARS of the Roses') that resulted in a new dynasty with a dramatic impact on the country: the Tudors, Henry VIII, and Elizabeth I and their descendants. Henry's story illustrates how schizophrenia can devastate individuals and families and change the course of history and yet it raises questions about how achievement and illness are related. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |
| 3 | Schizophr. Res. 2003 Sep 63: 131-5 |
| PMID | 12892867 |
| Title | No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel. |
| Abstract | Maternal stress during pregnancy is a possible risk factor for schizophrenia in the offspring. Using data from the Israel Psychiatric Registry we examined the impact of WARS in Israel. Retrospective birth cohort study. Relative risks for cohorts exposed to Six-Day War and Yom Kippur War were 0.98 (95% CI: 0.85-1.13) and 1.00 (0.86-1.16). The evidence for maternal stress as a risk factor for schizophrenia remains insufficient. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |
| 4 | Acad Psychiatry 2015 Dec 39: 719-25 |
| PMID | 25933645 |
| Title | Teaching Psychopathology in a Galaxy Far, Far Away: The Light Side of the Force. |
| Abstract | Star WARS films are among the top box office hits of all time. The films have been popular internationally for almost 40 years. As such, both trainees and attending psychiatrists are likely to be aware of them. This article highlights a vast array of psychopathology in Star WARS films which can be useful in teaching, even when the characters are considered the "good guys". Included are as follows: histrionic, obsessive-compulsive, and dependent personality traits, perinatal psychiatric disorders, prodromal schizophrenia, pseudo-dementia, frontal lobe lesions, pathological gambling, and even malingering. As such, Star WARS has tremendous potential to teach psychiatric trainees about mental health issues. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |