Gene Page: CHEK2

Summary
GeneID  11200
Symbol  CHEK2
Synonyms  CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53
Description  CHK2 checkpoint homolog (S. pombe)
See related  HGNC:16627|MIM:604373|Ensembl:ENSG00000183765|HPRD:05084|
Locus tag  RP11-436C9.1
Gene type  protein-coding
Map location  22q11|22q12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIPI12402044 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004674protein serine/threonine kinase activityTAS9836640 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000077DNA damage checkpointTAS9889122 |10617473 
GO:0006468protein amino acid phosphorylationIEA-
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosisIDA12402044 
GO:0007049cell cycleIEA-
GO:0010332response to gamma radiationIEA-
GO:0042770DNA damage response, signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0016605PML bodyIDA12402044 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedATM phosphorylates Chk2 at threonine 68.BIND15790808 
ATM phosphorylates Chk2 at threonine 68.BIND15064416 
ATMINASCIZ | DKFZp779K1455 | FLJ76795 | KIAA0431 | ZNF822ATM interactorASCIZ interacts with an unspecified isoform of CHK2.BIND15933716 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10724175 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetAffinity Capture-WesternBioGRID17525332 
DBF4ASK | CHIF | DBF4A | ZDBF1DBF4 homolog (S. cerevisiae)-HPRD,BioGRID12441400 
ERCC6ARMD5 | CKN2 | COFS | COFS1 | CSB | RAD26excision repair cross-complementing rodent repair deficiency, complementation group 6-HPRD9450932 
GINS2HSPC037 | PSF2 | Pfs2GINS complex subunit 2 (Psf2 homolog)Affinity Capture-WesternBioGRID17525332 
MDC1DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1mediator of DNA damage checkpoint 1-HPRD,BioGRID12551934 |12607004 
MRC1CD206 | CLEC13D | MMRmannose receptor, C type 1-HPRD11715017 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)-HPRD,BioGRID12447371 
MUS81FLJ21012 | FLJ44872MUS81 endonuclease homolog (S. cerevisiae)-HPRD,BioGRID11741546 
PLK1PLK | STPK13polo-like kinase 1 (Drosophila)-HPRD,BioGRID12493754 
PLK3CNK | FNK | PRKpolo-like kinase 3 (Drosophila)-HPRD,BioGRID12242661 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID17525332 
RAD9ARAD9RAD9 homolog A (S. pombe)-HPRD12049741 
TP53BP153BP1 | FLJ41424 | MGC138366 | p202tumor protein p53 binding protein 1Affinity Capture-WesternBioGRID17525332 
TSSK1BFKSG81 | SPOGA4 | STK22D | TSSK1testis-specific serine kinase 1B-HPRD12556502 
VCPIBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97valosin-containing proteinAffinity Capture-WesternBioGRID17525332 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
BIOCARTA_ATM_PATHWAY 2016All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_ATRBRCA_PATHWAY 2112All SZGR genes in this pathway
PID_ATM_PATHWAY 3425All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 5131All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_G2_M_CHECKPOINTS 4523All SZGR genes in this pathway
REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT 128All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
KAUFFMANN_MELANOMA_RELAPSE_UP 6125All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_ONLY_DN 4430All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_ES_2 4021All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY 3323All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2 182102All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway


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