Gene Page: CKS1B

Summary
GeneID  1163
Symbol  CKS1B
Synonyms  CKS1|PNAS-16|PNAS-18|ckshs1
Description  CDC28 protein kinase regulatory subunit 1B
See related  HGNC:19083|MIM:116900|Ensembl:ENSG00000173207|HPRD:00299|
Locus tag  RP11-307C12.6
Gene type  protein-coding
Map location  1q21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9276444 |12813041 
GO:0016538cyclin-dependent protein kinase regulator activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000079regulation of cyclin-dependent protein kinase activityTAS8601310 
GO:0007049cell cycleIEA-
GO:0008283cell proliferationTAS2227411 
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005654nucleoplasmEXP11231585 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCNA2CCN1 | CCNAcyclin A2Affinity Capture-WesternBioGRID11907280 
CDK2p33(CDK2)cyclin-dependent kinase 2-HPRD,BioGRID8601310 |12140288 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)Biochemical Activity
Reconstituted Complex		BioGRID12140288 |12813041 
CKS1BCKS1 | PNAS-16 | PNAS-18 | ckshs1CDC28 protein kinase regulatory subunit 1B-HPRD7791211 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)Affinity Capture-Western
Reconstituted Complex		BioGRID11231585 |12140288 
|12813041 
-HPRD11231585 |12813041 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
BIOCARTA_P27_PATHWAY 1310All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN 4525All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN 8749All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_TUMOR_SAMPLE_UP 1612All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN 3823All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_UP 8054All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_UP 8649All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 3818All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS 3020All SZGR genes in this pathway
YU_MYC_TARGETS_UP 4226All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
LY_AGING_PREMATURE_DN 3017All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C6 3927All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
RHODES_UNDIFFERENTIATED_CANCER 6944All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 2317All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P6 9144All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN 5029All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_HP_DN 4723All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4943843911A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.