Gene Page: DLG1

Summary
GeneID  1739
Symbol  DLG1
Synonyms  DKFZp761P0818|DKFZp781B0426|DLGH1|SAP97|dJ1061C18.1.1|hdlg
Description  discs, large homolog 1 (Drosophila)
See related  HGNC:2900|MIM:601014|Ensembl:ENSG00000075711|HPRD:03007|
Locus tag  -
Gene type  protein-coding
Map location  3q29
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2622 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0004721phosphoprotein phosphatase activityTAS15302935 
GO:0004385guanylate kinase activityTAS7937897 
GO:0019902phosphatase bindingIPI10646847 
GO:0008092cytoskeletal protein bindingTAS8825652 
GO:0008022protein C-terminus bindingIPI11274188 
GO:0015459potassium channel regulator activityNAS10779557 
GO:0019901protein kinase bindingIPI9341123 |10779557 |14699157 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001935endothelial cell proliferationIDA14699157 
GO:0007163establishment or maintenance of cell polarityTAS12766944 
GO:0007015actin filament organizationIDA14699157 
GO:0016337cell-cell adhesionIDA14699157 
GO:0031575G1/S transition checkpointNAS10656683 
GO:0030866cortical actin cytoskeleton organizationIDA14699157 
GO:0045930negative regulation of mitotic cell cycleIMP10656683 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005911cell-cell junctionTAS7937897 
GO:0005886plasma membraneTAS10859302 
GO:0016323basolateral plasma membraneIDA8922391 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN2CMD1AAactinin, alpha 2-HPRD,BioGRID12860415 
ADAM17CD156b | MGC71942 | TACE | cSVPADAM metallopeptidase domain 17PDZ domain of SAP97 interacts with C-terminal tail of TACE.BIND12668732 
-HPRD,BioGRID12668732 
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD10939335 
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1Affinity Capture-WesternBioGRID14960569 
ATP2B2PMCA2 | PMCA2a | PMCA2iATPase, Ca++ transporting, plasma membrane 2PMCA2b interacts with SAP97.BIND11274188 
-HPRD,BioGRID11274188 
ATP2B4ATP2B2 | DKFZp686G08106 | DKFZp686M088 | MXRA1 | PMCA4 | PMCA4b | PMCA4xATPase, Ca++ transporting, plasma membrane 4Reconstituted ComplexBioGRID12511555 
-HPRD11274188 
PMCA4b interacts with SAP97. This interaction was modeled on a demonstrated interaction between human PMCA4b and rat SAP97.BIND11274188 
BEGAINKIAA1446brain-enriched guanylate kinase-associated homolog (rat)-HPRD9756850 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containingAffinity Capture-Western
Reconstituted Complex		BioGRID12902344 
CACNG2MGC138502 | MGC138504calcium channel, voltage-dependent, gamma subunit 2Affinity Capture-WesternBioGRID11140673 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alpha-HPRD,BioGRID12933808 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10993877 |12151521 
|12351654 |14960569 
CASK interacts with DLG1 (SAP97).BIND15729360 
-HPRD10993877 |12351654 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD9512503 
CRIPTHSPC139cysteine-rich PDZ-binding protein-HPRD,BioGRID12070168 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID9512503 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD9512503 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID12351654 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD,BioGRID12351654 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-WesternBioGRID9286858 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1-HPRD,BioGRID9286858 
hDLG interacts with DAP-1alpha.BIND9286858 
DLGAP1 (GKAP) interacts with DLG1 (SAP97).BIND15729360 
hDLG interacts with DAP-1beta.BIND9286858 
DLGAP2DAP2 | SAPAP2discs, large (Drosophila) homolog-associated protein 2hDLG interacts with DAP-2.BIND9286858 
DLGAP4DAP4 | KIAA0964 | MGC131862 | RP5-977B1.6 | SAPAP4discs, large (Drosophila) homolog-associated protein 4-HPRD9115257 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD,BioGRID7937897 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD,BioGRID12175853 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD,BioGRID11726633 
GDACYPIN | GUANASE | KIAA1258 | MGC9982 | NEDASINguanine deaminase-HPRD10595517 
GPR124DKFZp434C211 | DKFZp434J0911 | FLJ14390 | KIAA1531 | TEM5G protein-coupled receptor 124Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15021905 
GPR125PGR21 | TEM5LG protein-coupled receptor 125-HPRD15021905 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD,BioGRID9677374 |11567040 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD,BioGRID11279111 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A-HPRD,BioGRID12933808 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2BAffinity Capture-WesternBioGRID11997254 
GUCY1A2GC-SA2 | GUC1A2guanylate cyclase 1, soluble, alpha 2-HPRD,BioGRID11572861 
KCNA4HBK4 | HK1 | HPCN2 | HUKII | KCNA4L | KCNA8 | KV1.4 | PCN2potassium voltage-gated channel, shaker-related subfamily, member 4-HPRD,BioGRID12860415 
KCNA5ATFB7 | HCK1 | HK2 | HPCN1 | KV1.5 | MGC117058 | MGC117059 | PCN1potassium voltage-gated channel, shaker-related subfamily, member 5Affinity Capture-WesternBioGRID12970345 
KCNAB1AKR6A3 | KCNA1B | KV-BETA-1 | Kvb1.3 | hKvBeta3 | hKvb3potassium voltage-gated channel, shaker-related subfamily, beta member 1-HPRD,BioGRID9341123 
KCNJ10BIRK-10 | KCNJ13-PEN | KIR1.2 | KIR4.1potassium inwardly-rectifying channel, subfamily J, member 10-HPRD9148889 
KCNJ12FLJ14167 | IRK2 | KCNJN1 | Kir2.2 | Kir2.2v | hIRK | hIRK1 | hkir2.2x | kcnj12xpotassium inwardly-rectifying channel, subfamily J, member 12-HPRD,BioGRID5024025 |11181181 
|14960569 
KCNJ2HHBIRK1 | HHIRK1 | IRK1 | KIR2.1 | LQT7 | SQT3potassium inwardly-rectifying channel, subfamily J, member 2-HPRD,BioGRID11181181 
KCNJ4HIR | HIRK2 | HRK1 | IRK3 | Kir2.3 | MGC142066 | MGC142068potassium inwardly-rectifying channel, subfamily J, member 4Affinity Capture-Western
Reconstituted Complex		BioGRID11181181 |14960569 
|15024025 
KCNJ6BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2potassium inwardly-rectifying channel, subfamily J, member 6Reconstituted ComplexBioGRID10619846 
KIF13BGAKIN | KIAA0639kinesin family member 13B-HPRD,BioGRID10859302 
KIF1BCMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844kinesin family member 1B-HPRD12097473 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9341123 
LIN7ALIN-7A | LIN7 | MALS-1 | MGC148143 | TIP-33 | VELI1lin-7 homolog A (C. elegans)Affinity Capture-WesternBioGRID14960569 
LIN7CFLJ11215 | LIN-7-C | LIN-7C | MALS-3 | MALS3 | VELI3lin-7 homolog C (C. elegans)Affinity Capture-WesternBioGRID14960569 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD12713445 
LRRC1FLJ10775 | FLJ11834 | LANO | dJ523E19.1leucine rich repeat containing 1Two-hybridBioGRID11440998 
MAP1AFLJ77111 | MAP1L | MTAP1Amicrotubule-associated protein 1A-HPRD9786987 
MRPS34MGC2616 | MRP-S12 | MRP-S34 | MRPS12mitochondrial ribosomal protein S34DLG1 (hDLG) interacts with MRPS34 (MRP-S34).BIND12507520 
MYO6DFNA22 | DFNB37 | KIAA0389myosin VI-HPRD12050163 
PBKFLJ14385 | Nori-3 | SPK | TOPKPDZ binding kinasePBK interacts with DLG1 (SAP97). This interaction was modelled on a demonstrated interaction between PBK from an unspecified species and human DLG1 (SAP97).BIND15729360 
-HPRD10779557 
SEMA4CFLJ20369 | KIAA1739 | M-SEMA-F | MGC126382 | MGC126383 | SEMACL1 | SEMAF | SEMAIsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C-HPRD11134026 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TJAP1DKFZp686F06131 | PILT | TJP4tight junction associated protein 1 (peripheral)-HPRD,BioGRID11602598 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 3123All SZGR genes in this pathway
REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 1111All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_UP 2717All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
APRELIKOVA_BRCA1_TARGETS 4933All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway


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