Gene Page: EIF5

Summary
GeneID  1983
Symbol  EIF5
Synonyms  EIF-5A
Description  eukaryotic translation initiation factor 5
See related  HGNC:3299|MIM:601710|Ensembl:ENSG00000100664|HPRD:03417|
Locus tag  -
Gene type  protein-coding
Map location  14q32.32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.502 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EPC10.970.94
NUP1600.960.94
KDM4A0.960.94
FUBP10.960.93
RAF10.960.95
VPRBP0.960.94
SETDB10.960.94
SSRP10.950.93
GART0.950.92
C9orf970.950.94
Top 10 negatively co-expressed genes
C5orf53-0.74-0.74
AF347015.31-0.73-0.88
AIFM3-0.73-0.76
AF347015.27-0.73-0.87
HLA-F-0.73-0.74
MT-CO2-0.72-0.89
FXYD1-0.72-0.87
IFI27-0.72-0.86
AF347015.33-0.71-0.85
S100B-0.71-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003743translation initiation factor activityNAS8663286 
GO:0003924GTPase activityTAS8663286 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS8663286 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS8663286 
GO:0005737cytoplasmTAS8663286 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa-HPRD,BioGRID9395514 |10805737 
|11092890 
EIF3GEIF3-P42 | EIF3S4 | eIF3-delta | eIF3-p44eukaryotic translation initiation factor 3, subunit G-HPRD,BioGRID9973622 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1-HPRD11331597 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_EIF_PATHWAY 169All SZGR genes in this pathway
BIOCARTA_EIF2_PATHWAY 118All SZGR genes in this pathway
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_DN 4629All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN 13686All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP 13680All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
SEIDEN_ONCOGENESIS_BY_MET 8853All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_5_DN 5935All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
SWEET_KRAS_TARGETS_DN 6639All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
ZHU_CMV_24_HR_UP 9365All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_DN 7849All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_UP 2719All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_UP 8962All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1019269321Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/10732391A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-1449259321A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-14957631Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-182196819741Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-2620912097m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-31103610431A,m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-494220226m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-542-3p171017161Ahsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
miR-9171617231A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96103910451Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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