Gene Page: FGFR3

Summary
GeneID  2261
Symbol  FGFR3
Synonyms  ACH|CD333|CEK2|HSFGFR3EX|JTK4
Description  fibroblast growth factor receptor 3
See related  HGNC:3690|MIM:134934|Ensembl:ENSG00000068078|HPRD:00624|
Locus tag  -
Gene type  protein-coding
Map location  4p16.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SCPEP10.540.58
AC051642.10.530.53
CORO60.520.56
ANKRD190.510.49
PLA2G4C0.500.54
CA70.500.55
HTATIP20.490.46
SLC48A10.490.54
TRPV30.490.51
PPAP2A0.490.49
Top 10 negatively co-expressed genes
BCL7C-0.40-0.49
C19orf57-0.38-0.32
DPYSL3-0.38-0.31
FAM109A-0.38-0.37
KIAA1949-0.37-0.34
ISYNA1-0.37-0.34
KCTD11-0.37-0.35
C1orf187-0.37-0.34
FBLIM1-0.37-0.35
KIAA1211-0.37-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005007fibroblast growth factor receptor activityIEA-
GO:0005007fibroblast growth factor receptor activityNAS7923141 
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0042802identical protein bindingIPI14732692 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0000165MAPKKK cascadeIEA-
GO:0000165MAPKKK cascadeTAS10918587 
GO:0001501skeletal system developmentTAS8601314 
GO:0002009morphogenesis of an epitheliumIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0016049cell growthNAS-
GO:0007259JAK-STAT cascadeTAS10918587 
GO:0008543fibroblast growth factor receptor signaling pathwayIEA-
GO:0008543fibroblast growth factor receptor signaling pathwayTAS10918587 
GO:0007605sensory perception of soundIEA-
GO:0043065positive regulation of apoptosisIEA-
GO:0031398positive regulation of protein ubiquitinationIEA-
GO:0050680negative regulation of epithelial cell proliferationIEA-
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0045597positive regulation of cell differentiationIEA-
GO:0060113inner ear receptor cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005764lysosomeIEA-
GO:0009898internal side of plasma membraneIEA-
GO:0005886plasma membraneEXP11294897 |16597617 
GO:0005887integral to plasma membraneTAS10918587 
GO:0048471perinuclear region of cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAP1CENTD2 | KIAA0782ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1Two-hybridBioGRID16169070 
ATF3-activating transcription factor 3Two-hybridBioGRID16169070 
C13orf34BORA | FLJ22624chromosome 13 open reading frame 34Two-hybridBioGRID16169070 
C6orf47D6S53E | G4 | NG34chromosome 6 open reading frame 47-HPRD,BioGRID14667819 
CCDC17FLJ17921 | FLJ33084coiled-coil domain containing 17Two-hybridBioGRID16169070 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
CTSKCTS02 | CTSO | CTSO1 | CTSO2 | MGC23107 | PKND | PYCDcathepsin KTwo-hybridBioGRID16169070 
FGF1AFGF | ECGF | ECGF-beta | ECGFA | ECGFB | FGF-alpha | FGFA | GLIO703 | HBGF1fibroblast growth factor 1 (acidic)-HPRD,BioGRID10574949 
FGF8AIGF | HBGF-8 | MGC149376fibroblast growth factor 8 (androgen-induced)-HPRD,BioGRID10574949 
FGF9GAF | HBFG-9 | MGC119914 | MGC119915fibroblast growth factor 9 (glia-activating factor)-HPRD,BioGRID8576175 |10574949 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID9045692 
GTF3C1DKFZp686A111 | TFIIIC | TFIIIC220 | TFIIICalphageneral transcription factor IIIC, polypeptide 1, alpha 220kDaTwo-hybridBioGRID16169070 
HBZ-hemoglobin, zetaTwo-hybridBioGRID16169070 
HNRNPLFLJ35509 | HNRPL | P/OKcl.14 | hnRNP-Lheterogeneous nuclear ribonucleoprotein LTwo-hybridBioGRID16169070 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
KRT8CARD2 | CK8 | CYK8 | K2C8 | K8 | KOkeratin 8Two-hybridBioGRID16169070 
NDUFS6-NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)Two-hybridBioGRID16169070 
POLA2FLJ21662 | FLJ37250polymerase (DNA directed), alpha 2 (70kD subunit)Two-hybridBioGRID16169070 
RADILFLJ10324 | KIAA1849 | MGC161589Rap GTPase interactorTwo-hybridBioGRID16169070 
RNF130G1RZFP | GOLIATH | GP | MGC117241 | MGC138647 | MGC99542ring finger protein 130Two-hybridBioGRID16169070 
RPL8-ribosomal protein L8Two-hybridBioGRID16169070 
SH2B1DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2BSH2B adaptor protein 1-HPRD,BioGRID11827956 
SLC25A6AAC3 | ANT3 | ANT3Y | MGC17525solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6Two-hybridBioGRID16169070 
SMG7C1orf16 | EST1C | FLJ23717 | KIAA0250 | SGA56M | SMG-7Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR3_MUTANTS 119All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS 4429All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 5440All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_CASCADE 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 2215All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_DN 2513All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_DN 2918All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_UP 2119All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN 4328All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SPIKED 2213All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MS_UP 4832All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8 7256All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_UP 7747All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
FINETTI_BREAST_CANCERS_KINOME_BLUE 2116All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_DN 7044All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_UP 3917All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP 8750All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1812963021Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-186112311291Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-194126212681Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-24422428m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-99/1005375441A,m8hsa-miR-99abrainAACCCGUAGAUCCGAUCUUGUG
hsa-miR-100brainAACCCGUAGAUCCGAACUUGUG
hsa-miR-99bbrainCACCCGUAGAACCGACCUUGCG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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