Gene Page: APC

Summary
GeneID  324
Symbol  APC
Synonyms  BTPS2|DP2|DP2.5|DP3|GS
Description  adenomatous polyposis coli
See related  HGNC:583|MIM:611731|Ensembl:ENSG00000134982|HPRD:01439|
Locus tag  -
Gene type  protein-coding
Map location  5q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0228 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
UQCRC10.880.85
NIT10.870.83
ARFIP20.870.83
ATP5B0.870.82
TBRG40.860.84
MRPL370.860.82
NDUFA100.860.81
SLC41A30.850.81
PREB0.850.83
RABGGTA0.850.81
Top 10 negatively co-expressed genes
AF347015.18-0.62-0.57
AF347015.21-0.61-0.50
AF347015.8-0.61-0.49
AL139819.3-0.60-0.59
AF347015.2-0.59-0.46
AF347015.26-0.59-0.49
MT-CO2-0.58-0.46
MT-ATP8-0.57-0.52
AF347015.33-0.56-0.48
MT-CYB-0.56-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008605protein kinase CK2 regulator activityIDA11972058 
GO:0008017microtubule bindingIDA11166179 |16188939 
GO:0008013beta-catenin bindingIPI11533658 
GO:0008013beta-catenin bindingNAS8259518 
GO:0019901protein kinase bindingIDA11283619 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionNAS8259518 
GO:0006461protein complex assemblyIDA16188939 
GO:0007026negative regulation of microtubule depolymerizationIDA11166179 
GO:0009953dorsal/ventral pattern formationIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0007050cell cycle arrestIDA8521819 
GO:0008285negative regulation of cell proliferationIDA8521819 
GO:0009798axis specificationIEA-
GO:0006974response to DNA damage stimulusIDA14728717 
GO:0045736negative regulation of cyclin-dependent protein kinase activityIDA8521819 
GO:0051988regulation of attachment of spindle microtubules to kinetochoreNAS11283619 
GO:0060070Wnt receptor signaling pathway through beta-cateninIC9601641 
GO:0060070Wnt receptor signaling pathway through beta-cateninNAS11035805 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000776kinetochoreIDA11283619 
GO:0005813centrosomeIDA11283619 
GO:0005829cytosolEXP11955436 |12000790 |12820959 
|15327769 |16753179 
GO:0005634nucleusIDA11035805 |12955080 
GO:0005737cytoplasmIDA11035805 |12955080 
GO:0016328lateral plasma membraneIDA12072559 
GO:0030877beta-catenin destruction complexIDA9601641 |16188939 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-Western
Reconstituted Complex		BioGRID8389242 |12070164 
ARHGEF4ASEF | ASEF1 | GEF4 | STM6Rho guanine nucleotide exchange factor (GEF) 4APC interacts with Asef. This interaction was modeled on a demonstrated interaction between human APC and Asef from an unspecified species.BIND15572129 
-HPRD,BioGRID10947987 
AXIN1AXIN | MGC52315axin 1Reconstituted Complex
Two-hybrid		BioGRID9734785 
-HPRD11297546 
AXIN2AXIL | DKFZp781B0869 | MGC10366 | MGC126582axin 2-HPRD,BioGRID10966653 
BUB1BUB1A | BUB1L | hBUB1budding uninhibited by benzimidazoles 1 homolog (yeast)-HPRD,BioGRID11283619 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)Biochemical ActivityBioGRID11283619 
BUB3BUB3L | hBUB3budding uninhibited by benzimidazoles 3 homolog (yeast)Affinity Capture-WesternBioGRID11283619 
CDC20CDC20A | MGC102824 | bA276H19.3 | p55CDCcell division cycle 20 homolog (S. cerevisiae)-HPRD9637688 |9811605 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptideAffinity Capture-Western
Reconstituted Complex		BioGRID11972058 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideAffinity Capture-WesternBioGRID11972058 
CTBP1BARS | MGC104684C-terminal binding protein 1CtBP interacts with APC.BIND15525529 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDaAffinity Capture-WesternBioGRID7651399 |8259519 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAPC interacts with Beta-catenin.BIND15525529 
-HPRD12000790 
Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc.BIND15294866 
Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex		BioGRID8259519 |9286858 
|11251183 |11533658 
|11707392 |11712088 
|11972058 |12628243 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9188857 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1-HPRD,BioGRID9286858 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-WesternBioGRID11251183 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1APC interacts with IQGAP1.BIND15572129 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinAffinity Capture-Western
Reconstituted Complex		BioGRID7651399 |8074697 
KIFAP3FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1kinesin-associated protein 3-HPRD,BioGRID11912492 
MAD2L1HSMAD2 | MAD2MAD2 mitotic arrest deficient-like 1 (yeast)-HPRD,BioGRID9637688 
MAPRE1EB1 | MGC117374 | MGC129946microtubule-associated protein, RP/EB family, member 1-HPRD,BioGRID11470413 |12388762 
MAPRE2EB1 | EB2 | RP1microtubule-associated protein, RP/EB family, member 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7606712 |11470413 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associatedAffinity Capture-WesternBioGRID15020226 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoformCo-localizationBioGRID11585828 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD7744883 
PTPN13DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLEprotein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)Affinity Capture-Western
Two-hybrid		BioGRID10951583 
RP1DCDC4A | ORP1retinitis pigmentosa 1 (autosomal dominant)-HPRD10188731 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)-HPRD,BioGRID11389840 
TFAP2AAP-2 | AP-2alpha | AP2TF | BOFS | TFAP2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Affinity Capture-Western
Reconstituted Complex		BioGRID15331612 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4aCo-localization
Reconstituted Complex		BioGRID11166179 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)Affinity Capture-Western
Reconstituted Complex		BioGRID12070164 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_PITX2_PATHWAY 1515All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY 2723All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY 3428All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
PID_BETA_CATENIN_DEG_PATHWAY 1817All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_CDC42_REG_PATHWAY 3022All SZGR genes in this pathway
PID_WNT_CANONICAL_PATHWAY 2018All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 1611All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_DN 5835All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_27 158All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_DN 3322All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_FREQUENTLY 1210All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_DN 147All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM 3215All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_UP 8455All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C3 1410All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP 3826All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
MILI_PSEUDOPODIA 4327All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_UP 7445All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
LI_PROSTATE_CANCER_EPIGENETIC 3022All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3513823881Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-129-5p4044111A,m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-142-3p3103171A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-153961967m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1559659711Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-203.18228291A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-26124812551A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-274624681Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-3p859865m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-330511517m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3743593651Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3817417471Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4484014071Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4504044101Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4968478531Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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