ACVR1B | ACTRIB | ACVRLK4 | ALK4 | SKR2 | activin A receptor, type IB | - | HPRD | 9892009 |
AKT1 | AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 | Affinity Capture-Western | BioGRID | 16362038 |
AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | - | HPRD,BioGRID | 12226080 |
ATF2 | CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7 | activating transcription factor 2 | - | HPRD,BioGRID | 10085140 |
BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | BRCA1 interacts with Smad4. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad4 from an unspecified species. | BIND | 15735739 |
BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | - | HPRD,BioGRID | 14988407 |
CAMK2G | CAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678 | calcium/calmodulin-dependent protein kinase II gamma | - | HPRD,BioGRID | 11027280 |
CDKN1A | CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Smad4 binds the distal region of the p21Cip1 promoter. | BIND | 15084259 |
CEBPA | C/EBP-alpha | CEBP | CCAAT/enhancer binding protein (C/EBP), alpha | Reconstituted Complex | BioGRID | 12524424 |
CEBPB | C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 | CCAAT/enhancer binding protein (C/EBP), beta | CEBPB (C/EBP-beta) interacts with SMAD4. This interaction was modeled on a demonstrated interaction between CEBPB and SMAD4, both from unspecified species. | BIND | 12202226 |
- | HPRD,BioGRID | 12524424 |
CEBPD | C/EBP-delta | CELF | CRP3 | NF-IL6-beta | CCAAT/enhancer binding protein (C/EBP), delta | Affinity Capture-Western Reconstituted Complex | BioGRID | 12524424 |
CITED1 | MSG1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | - | HPRD,BioGRID | 9707553 |
COPS5 | CSN5 | JAB1 | MGC3149 | MOV-34 | SGN5 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) | - | HPRD,BioGRID | 11818334 |
CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | - | HPRD,BioGRID | 12000714 |
DACH1 | DACH | FLJ10138 | dachshund homolog 1 (Drosophila) | - | HPRD | 14525983 |
DCP1A | FLJ21691 | HSA275986 | Nbla00360 | SMAD4IP1 | SMIF | DCP1 decapping enzyme homolog A (S. cerevisiae) | - | HPRD,BioGRID | 11836524 |
DLX1 | - | distal-less homeobox 1 | - | HPRD,BioGRID | 14671321 |
DVL1 | DVL | MGC54245 | dishevelled, dsh homolog 1 (Drosophila) | Reconstituted Complex | BioGRID | 12650946 |
ECSIT | SITPEC | ECSIT homolog (Drosophila) | - | HPRD | 14633973 |
EID2 | CRI2 | EID-2 | MGC20452 | EP300 interacting inhibitor of differentiation 2 | - | HPRD,BioGRID | 14612439 |
EP300 | KAT3B | p300 | E1A binding protein p300 | Affinity Capture-Western | BioGRID | 10887155 |
p300 interacts with Smad4 fragment. p300 interacting with full-length Smad4 could not be demonstrated in vitro. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad4 fragment. | BIND | 9679056 |
ERBB2IP | ERBIN | LAP2 | erbb2 interacting protein | - | HPRD,BioGRID | 12650946 |
EWSR1 | EWS | Ewing sarcoma breakpoint region 1 | Two-hybrid | BioGRID | 16189514 |
FOXH1 | FAST-1 | FAST1 | forkhead box H1 | Reconstituted Complex Two-hybrid | BioGRID | 9288972 |
FOXO1 | FKH1 | FKHR | FOXO1A | forkhead box O1 | FoxO1 interacts with Smad4. | BIND | 15084259 |
- | HPRD,BioGRID | 15084259 |
FOXO3 | AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925 | forkhead box O3 | - | HPRD,BioGRID | 15084259 |
FoxO3 interacts with Smad4. | BIND | 15084259 |
FOXO4 | AFX | AFX1 | MGC120490 | MLLT7 | forkhead box O4 | - | HPRD,BioGRID | 15084259 |
FoxO4 interacts with Smad4. | BIND | 15084259 |
FSTL3 | FLRG | FSRP | follistatin-like 3 (secreted glycoprotein) | - | HPRD | 11571638 |
GLI3 | ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIV | GLI-Kruppel family member GLI3 | - | HPRD | 9843199 |
HOXA9 | ABD-B | HOX1 | HOX1.7 | HOX1G | MGC1934 | homeobox A9 | - | HPRD,BioGRID | 11042172 |
HOXC8 | HOX3 | HOX3A | homeobox C8 | - | HPRD,BioGRID | 10224145 |
JUN | AP-1 | AP1 | c-Jun | jun oncogene | - | HPRD | 10220381 |
JUNB | AP-1 | jun B proto-oncogene | - | HPRD,BioGRID | 10220381 |
JUND | AP-1 | jun D proto-oncogene | - | HPRD | 10220381 |
KPNB1 | IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 | karyopherin (importin) beta 1 | Affinity Capture-Western | BioGRID | 10846168 |
LEF1 | DKFZp586H0919 | TCF1ALPHA | lymphoid enhancer-binding factor 1 | - | HPRD,BioGRID | 10890911 |
MAX | MGC10775 | MGC11225 | MGC18164 | MGC34679 | MGC36767 | bHLHd4 | orf1 | MYC associated factor X | - | HPRD,BioGRID | 12551947 |
MDM4 | DKFZp781B1423 | HDMX | MDMX | MGC132766 | MRP1 | Mdm4 p53 binding protein homolog (mouse) | Reconstituted Complex | BioGRID | 12483531 |
MED15 | ARC105 | CAG7A | CTG7A | DKFZp686A2214 | DKFZp762B1216 | FLJ42282 | FLJ42935 | PCQAP | TIG-1 | TIG1 | TNRC7 | mediator complex subunit 15 | - | HPRD | 12167862 |
MEF2A | ADCAD1 | RSRFC4 | RSRFC9 | myocyte enhancer factor 2A | - | HPRD | 11160896 |
PARD3B | ALS2CR19 | MGC16131 | PAR3B | PAR3L | PAR3LC | PAR3beta | Par3Lb | par-3 partitioning defective 3 homolog B (C. elegans) | Reconstituted Complex | BioGRID | 12650946 |
PIAS3 | FLJ14651 | ZMIZ5 | protein inhibitor of activated STAT, 3 | - | HPRD,BioGRID | 14691252 |
PIAS4 | FLJ12419 | MGC35296 | PIASY | Piasg | ZMIZ6 | protein inhibitor of activated STAT, 4 | Affinity Capture-Western | BioGRID | 12815042 |
RBL1 | CP107 | MGC40006 | PRB1 | p107 | retinoblastoma-like 1 (p107) | - | HPRD,BioGRID | 12150994 |
SKI | SKV | v-ski sarcoma viral oncogene homolog (avian) | - | HPRD,BioGRID | 12419246 |12857746
|
Smad4 interacts with Ski. This interaction was modeled on a demonstrated interaction between human Smad4 and Ski from an unspecified species. | BIND | 15761153 |
c-Ski interacts with Smad4. This interaction was modelled on a demonstrated interaction between Smad4 from an unspecified source and human c-Ski. | BIND | 10575014 |
SKIL | SNO | SnoA | SnoN | SKI-like oncogene | Smad4 interacts with SnoN. This interaction was modeled on a demonstrated interaction between human Smad4 and SnoN from an unspecified species. | BIND | 15761153 |
- | HPRD,BioGRID | 10531062 |
SMAD1 | BSP1 | JV4-1 | JV41 | MADH1 | MADR1 | SMAD family member 1 | - | HPRD | 10400705 |11700304
|
Affinity Capture-Western Co-fractionation | BioGRID | 10531362 |11700304 |12874272 |
Smad4 interacts with Smad1. | BIND | 15761153 |
SMAD2 | JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 | SMAD family member 2 | - | HPRD,BioGRID | 11274206 |
Smad4 interacts with Smad2. | BIND | 15761153 |
Smad2 interacts with Smad4. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified species and Smad4 from an unspecified species. | BIND | 9311995 |
SMAD3 | DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 | SMAD family member 3 | - | HPRD | 9311995|9732876 |
Smad3 interacts with Smad4. This interaction was modeled on a demonstrated interaction between Smad3 from an unspecified species and Smad4 from an unspecified species. | BIND | 9311995 |
Smad4 interacts with Smad3. | BIND | 15761153 |
Affinity Capture-Western | BioGRID | 9311995 |9892009 |10531362 |11114293 |12419246 |12794086 |15084259 |
SMAD5 | DKFZp781C1895 | DKFZp781O1323 | Dwfc | JV5-1 | MADH5 | SMAD family member 5 | Affinity Capture-Western | BioGRID | 10531362 |
SMAD7 | CRCS3 | FLJ16482 | MADH7 | MADH8 | SMAD family member 7 | Phenotypic Suppression | BioGRID | 9892009 |
SMAD9 | MADH6 | MADH9 | SMAD8A | SMAD8B | SMAD family member 9 | Affinity Capture-Western Two-hybrid | BioGRID | 10583507 |16189514
|
SNIP1 | FLJ12553 | RP3-423B22.3 | dJ423B22.2 | Smad nuclear interacting protein 1 | - | HPRD,BioGRID | 10887155 |
SNW1 | Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIP | SNW domain containing 1 | Phenotypic Enhancement Two-hybrid | BioGRID | 11278756 |
SP1 | - | Sp1 transcription factor | - | HPRD | 11432852 |
SPTBN1 | ELF | SPTB2 | betaSpII | spectrin, beta, non-erythrocytic 1 | - | HPRD | 12543979 |
STK11IP | KIAA1898 | LIP1 | LKB1IP | STK11IP1 | serine/threonine kinase 11 interacting protein | - | HPRD,BioGRID | 11741830 |
STUB1 | CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1 | STIP1 homology and U-box containing protein 1 | Smad4 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species. | BIND | 15708501 |
SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | SMAD4 is sumoylated. | BIND | 15592428 |
TFE3 | RCCP2 | TFEA | bHLHe33 | transcription factor binding to IGHM enhancer 3 | - | HPRD,BioGRID | 10557285 |
TGFB1I1 | ARA55 | HIC-5 | HIC5 | TSC-5 | transforming growth factor beta 1 induced transcript 1 | ARA55 interacts with Smad4. This interaction was modeled on a demonstrated interaction between human ARA55 and Smad4 from an unspecified species. | BIND | 15561701 |
TGFBR1 | AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 | transforming growth factor, beta receptor 1 | T-beta-RI phosphorylates hMAD-4. This interaction was modeled on a demonstrated interaction between T-beta-RI from an unspecified species and human hMAD-4. | BIND | 8774881 |
Co-fractionation | BioGRID | 11102446 |
TGFBR2 | AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RII | transforming growth factor, beta receptor II (70/80kDa) | T-beta-RII phosphorylates hMAD-4. This interaction was modeled on a demonstrated interaction between T-beta-RII from an unspecified species and human hMAD-4. | BIND | 8774881 |
TGFBRAP1 | TRAP-1 | TRAP1 | transforming growth factor, beta receptor associated protein 1 | - | HPRD,BioGRID | 11278302 |
TOB1 | APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1 | transducer of ERBB2, 1 | - | HPRD,BioGRID | 11163184 |
TRIM33 | FLJ32925 | PTC7 | RFG7 | TF1G | TIF1G | TIF1GAMMA | TIFGAMMA | tripartite motif-containing 33 | Smad4 interacts with Ecto. | BIND | 15820681 |
TSSK3 | SPOGA3 | STK22C | STK22D | testis-specific serine kinase 3 | SMAD4 interacts with STK22C. This interaction was modeled on a demonstrated interaction between human SMAD4 and mouse STK22C. | BIND | 15761153 |
UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Two-hybrid | BioGRID | 16189514 |
UBE2L3 | E2-F1 | L-UBC | UBCH7 | UbcM4 | ubiquitin-conjugating enzyme E2L 3 | - | HPRD | 12794086 |
ZNF423 | Ebfaz | KIAA0760 | MGC138520 | MGC138522 | OAZ | Roaz | ZFP423 | Zfp104 | zinc finger protein 423 | - | HPRD,BioGRID | 10660046 |
ZNF521 | DKFZp564D0764 | EHZF | Evi3 | MGC142182 | MGC142208 | zinc finger protein 521 | - | HPRD | 14630787 |
ZNF8 | HF.18 | Zfp128 | zinc finger protein 8 | - | HPRD | 12370310 |