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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: PFN2

Summary

GeneID

5217

Symbol

PFN2

Synonyms

D3S1319E|PFL

Description

profilin 2

Locus tag

Gene type

protein-coding

Map location

3q25.1-q25.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0086

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003779

actin binding

NAS

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

NAS

GO:0005515

protein binding

IPI

15383276 |16169070

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007010

cytoskeleton organization

IEA

GO:0008064

regulation of actin polymerization or depolymerization

NAS

GO:0030036

actin cytoskeleton organization

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

GO:0015629

actin cytoskeleton

NAS

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	-	HPRD	10600384
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16169070
CCDC113	DKFZp434N1418 \| FLJ23555 \| HSPC065	coiled-coil domain containing 113	Two-hybrid	BioGRID	16169070
DDX11	CHL1 \| CHLR1 \| KRG2 \| MGC133249 \| MGC9335	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)	Two-hybrid	BioGRID	16169070
DLST	DLTS	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	Two-hybrid	BioGRID	16169070
DNM1	DNM	dynamin 1	-	HPRD	9463375
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	Two-hybrid	BioGRID	16169070
EVL	RNB6	Enah/Vasp-like	-	HPRD,BioGRID	10945997
FAM173A	C16orf24 \| MGC2494	family with sequence similarity 173, member A	Two-hybrid	BioGRID	16169070
FHOD1	FHOS	formin homology 2 domain containing 1	Two-hybrid	BioGRID	12677009
			PFN IIa interacts with FHOS.	BIND	12677009
			PFN IIa interacts with FHOS78.	BIND	12677009
FMNL1	C17orf1 \| C17orf1B \| FHOD4 \| FMNL \| KW-13 \| MGC133052 \| MGC1894 \| MGC21878	formin-like 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10958683
GOLGB1	GCP \| GCP372 \| GIANTIN \| GOLIM1	golgin B1, golgi integral membrane protein	Two-hybrid	BioGRID	16169070
IK	CSA2 \| MGC59741 \| RED	IK cytokine, down-regulator of HLA II	Two-hybrid	BioGRID	16169070
IVNS1ABP	DKFZp686K06216 \| FLARA3 \| FLJ10069 \| FLJ10411 \| FLJ10962 \| FLJ35593 \| FLJ36593 \| HSPC068 \| KIAA0850 \| ND1 \| NS-1 \| NS1-BP \| NS1BP	influenza virus NS1A binding protein	Two-hybrid	BioGRID	16169070
LOC339344	-	hypothetical protein LOC339344	-	HPRD	15615774
NDUFB8	ASHI \| CI-ASHI	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	Two-hybrid	BioGRID	16169070
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
RAP1GAP	KIAA0474 \| RAP1GA1 \| Rap1GAP1 \| rap1GAPII	RAP1 GTPase activating protein	Two-hybrid	BioGRID	16169070
RNF146	DKFZp434O1427 \| RP3-351K20.1 \| dJ351K20.1	ring finger protein 146	Two-hybrid	BioGRID	16169070
ROCK1	MGC131603 \| MGC43611 \| P160ROCK \| PRO0435	Rho-associated, coiled-coil containing protein kinase 1	-	HPRD,BioGRID	14517206
RPS10	MGC88819	ribosomal protein S10	Two-hybrid	BioGRID	16169070
SEPT5	CDCREL \| CDCREL-1 \| CDCREL1 \| H5 \| PNUTL1	septin 5	Two-hybrid	BioGRID	16169070
SGTA	SGT \| alphaSGT \| hSGT	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	Two-hybrid	BioGRID	16169070
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-Western	BioGRID	12391155
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	9463375
TERF1	FLJ41416 \| PIN2 \| TRBF1 \| TRF \| TRF1 \| hTRF1-AS \| t-TRF1	telomeric repeat binding factor (NIMA-interacting) 1	Two-hybrid	BioGRID	16169070
VASP	-	vasodilator-stimulated phosphoprotein	-	HPRD,BioGRID	7737110 \|10882740
WDR33	FLJ11294 \| WDC146	WD repeat domain 33	Two-hybrid	BioGRID	16169070

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	35	25	All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY	65	54	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_DN	92	51	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN	781	465	All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN	136	94	All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP	120	73	All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN	120	73	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN	234	147	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	612	367	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP	271	175	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN	62	44	All SZGR genes in this pathway
HU_ANGIOGENESIS_DN	37	25	All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER	178	108	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP	209	139	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP	398	262	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN	546	351	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION	475	313	All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_DN	30	21	All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN	162	102	All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN	48	26	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8	72	56	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN	434	302	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2	473	224	All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP	66	44	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G	95	62	All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G	171	96	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN	543	317	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN	593	372	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN	591	366	All SZGR genes in this pathway
POS_RESPONSE_TO_HISTAMINE_UP	13	10	All SZGR genes in this pathway
POS_HISTAMINE_RESPONSE_NETWORK	32	22	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP	648	398	All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C	463	262	All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP	425	253	All SZGR genes in this pathway
CROMER_TUMORIGENESIS_UP	63	36	All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6	456	285	All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2	356	214	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN	181	97	All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP	188	121	All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP	105	75	All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP	166	105	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16	79	47	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_1_UP	125	61	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_2_UP	54	31	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP	170	97	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_UP	112	64	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP	140	81	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP	118	68	All SZGR genes in this pathway
CARD_MIR302A_TARGETS	77	62	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN	336	211	All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_DN	41	27	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA	208	107	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-133	866	872	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	866	872	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-138	767	773	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-150	401	407	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d	350	356	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-183	959	966	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-183	959	966	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-19	761	768	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	761	768	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-194	1151	1157	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-218	192	198	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	1226	1233	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-342	993	999	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-409-5p	692	698	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-448	1188	1194	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-488	836	842	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-488	836	842	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-493-5p	1093	1099	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	1149	1155	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-7	379	385	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	349	355	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.