Gene Page: EXOSC4

Summary
GeneID  54512
Symbol  EXOSC4
Synonyms  FLJ20591|RRP41|RRP41A|Rrp41p|SKI6|Ski6p|hRrp41p|p12A
Description  exosome component 4
See related  HGNC:18189|MIM:606491|Ensembl:ENSG00000178896|HPRD:16221|
Locus tag  -
Gene type  protein-coding
Map location  8q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.385 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00001753'-5'-exoribonuclease activityNAS11110791 
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI15231747 
GO:0004527exonuclease activityIEA-
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006396RNA processingIEA-
GO:0006364rRNA processingNAS11110791 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000178exosome (RNase complex)IEA-
GO:0005634nucleusIEA-
GO:0005730nucleolusNAS11110791 
GO:0005737cytoplasmNAS11110791 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKR1A1ALDR1 | ALR | ARM | DD3 | MGC12529 | MGC1380aldo-keto reductase family 1, member A1 (aldehyde reductase)-HPRD,BioGRID15231747 
DOM3ZDOM3L | NG6dom-3 homolog Z (C. elegans)-HPRD15231747 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1-HPRD,BioGRID15231747 
EXOSC1CGI-108 | CSL4 | Csl4p | SKI4 | Ski4p | hCsl4p | p13exosome component 1-HPRD11110791 |12419256 
hCsl4p interacts with hRrp41p.BIND12419256 
EXOSC10PM-Scl | PM/Scl-100 | PMSCL | PMSCL2 | RRP6 | Rrp6p | p2 | p3 | p4exosome component 10-HPRD15231747 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2-HPRD12419256 
-HPRD11719186 
hRrp4p interacts with hRrp41p.BIND12419256 
EXOSC3CGI-102 | MGC15120 | MGC723 | RP11-3J10.8 | RRP40 | Rrp40p | bA3J10.7 | hRrp40p | p10exosome component 3-HPRD11110791 |12419256 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4hRrp41p interacts with another hRrp41p.BIND12419256 
-HPRD12419256 
EXOSC7EAP1 | FLJ26543 | KIAA0116 | RRP42 | Rrp42p | hRrp42p | p8exosome component 7hRrp42p interacts with hRrp41p.BIND12419256 
EXOSC9PM/Scl-75 | PMSCL1 | RRP45 | Rrp45p | p5 | p6exosome component 9PM/Scl-75c-alpha interacts with hRrp41p.BIND12788944 
GADD45GIP1CKBBP2 | CRIF1 | MGC4667 | MGC4758 | PLINP-1 | PRG6 | Plinp1growth arrest and DNA-damage-inducible, gamma interacting protein 1-HPRD15231747 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1-HPRD,BioGRID15231747 
LRRC8DFLJ10470 | FLJ20403 | LRRC5leucine rich repeat containing 8 family, member D-HPRD15231747 
MPZL1FLJ21047 | PZR | PZR1b | PZRa | PZRbmyelin protein zero-like 1-HPRD15231747 
NEK1DKFZp686D06121 | DKFZp686K12169 | KIAA1901 | MGC138800 | NY-REN-55NIMA (never in mitosis gene a)-related kinase 1-HPRD15231747 
SKIV2L170A | DDX13 | HLP | SKI2 | SKI2W | SKIV2superkiller viralicidic activity 2-like (S. cerevisiae)-HPRD15231747 
SMPD4FLJ20297 | FLJ20756 | KIAA1418 | NSMASE3 | nSMase-3sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)-HPRD15231747 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)-HPRD,BioGRID14527413 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)-HPRD,BioGRID14527413 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Affinity Capture-WesternBioGRID14527413 
UPF3BHUPF3B | MRXS14 | RENT3B | UPF3XUPF3 regulator of nonsense transcripts homolog B (yeast)-HPRD14527413 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RNA_DEGRADATION 5937All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PERK_REGULATED_GENE_EXPRESSION 2914All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_GENES_BY_ATF4 2612All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE 8051All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE 115All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 4829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 179All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP 179All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 177All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_DN 2919All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
OXFORD_RALA_OR_RALB_TARGETS_UP 4823All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_5_UP 3423All SZGR genes in this pathway
SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP 1914All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON 15787All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway


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