Gene Page: BRAF

Summary
GeneID  673
Symbol  BRAF
Synonyms  B-RAF1|BRAF1|FLJ95109|MGC126806|MGC138284|RAFB1
Description  v-raf murine sarcoma viral oncogene homolog B1
See related  HGNC:1097|MIM:164757|Ensembl:ENSG00000157764|HPRD:01264|
Locus tag  -
Gene type  protein-coding
Map location  7q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0286 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZFP36L20.850.87
SOX90.830.73
FBXL70.830.85
SLC2A100.810.80
PALLD0.790.75
NR2E10.780.76
CRB20.780.75
YAP10.770.83
NFATC40.770.71
SIX50.770.64
Top 10 negatively co-expressed genes
SYCP3-0.24-0.26
ZBTB8OS-0.22-0.28
USMG5-0.21-0.30
THOC7-0.21-0.25
AF347015.21-0.21-0.15
AL050337.1-0.21-0.27
DDTL-0.20-0.30
BEX5-0.20-0.15
GNRHR-0.20-0.26
FABP3-0.20-0.12
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005057receptor signaling protein activityIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0019992diacylglycerol bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS2284096 
GO:0009887organ morphogenesisTAS9207797 
GO:0007264small GTPase mediated signal transductionEXP10712923 
GO:0006916anti-apoptosisTAS9207797 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID10869359 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID7706312 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1MEK1 interacts with B-Raf.BIND8621729 
-HPRD7731720 
MAP2K2FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2mitogen-activated protein kinase kinase 2-HPRD8668348 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Phenotypic EnhancementBioGRID10869359 
MRASFLJ42964 | M-RAs | R-RAS3 | RRAS3muscle RAS oncogene homolog-HPRD,BioGRID12138204 
OIP55730547N13Rik | LINT-25 | MIS18betaOpa interacting protein 5B-RAF interacts with OIP5.BIND12620389 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1B-RAF interacts with C-RAF. This interaction was modelled on a demonstrated interaction between human B-RAF and monkey C-RAF .BIND15035987 
-HPRD,BioGRID11325826 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyReconstituted ComplexBioGRID10454553 
RAP1GAPKIAA0474 | RAP1GA1 | Rap1GAP1 | rap1GAPIIRAP1 GTPase activating proteinReconstituted ComplexBioGRID11278445 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
TIMM50MGC102733 | TIM50 | TIM50Ltranslocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)B-RAF interacts with TIMM50.BIND12620389 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideBRAF (B-Raf) interacts with an unspecified isoform of YWHAB (14-3-3-beta).BIND12620389 
B-RAF interacts with 14-3-3-beta.BIND12620389 
-HPRD,BioGRID10931830 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD8668348 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD8668348 
Affinity Capture-MSBioGRID17353931 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideAffinity Capture-MSBioGRID17353931 
-HPRD8668348 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
ST_G_ALPHA_S_PATHWAY 1611All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY 1414All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 149All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 2723All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 3328All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
SU_TESTIS 7653All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP 7353All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway


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