Gene Page: TGFB1

Summary
GeneID  7040
Symbol  TGFB1
Synonyms  CED|DPD1|TGFB|TGFbeta
Description  transforming growth factor, beta 1
See related  HGNC:11766|MIM:190180|Ensembl:ENSG00000105329|HPRD:01821|
Locus tag  -
Gene type  protein-coding
Map location  19q13.2|19q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0382 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CENPM0.910.61
CDC45L0.900.59
MCM50.900.67
FAM83D0.890.61
AC087645.20.890.64
PCNA0.890.73
TACC30.890.63
ASF1B0.880.62
PLK10.880.65
FAM64A0.880.63
Top 10 negatively co-expressed genes
AF347015.31-0.39-0.59
AF347015.27-0.39-0.61
MT-CO2-0.38-0.60
C5orf53-0.38-0.44
AF347015.33-0.38-0.61
AF347015.8-0.38-0.62
AF347015.15-0.38-0.62
MT-CYB-0.37-0.60
AIFM3-0.37-0.46
AF347015.2-0.36-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005114type II transforming growth factor beta receptor bindingIDA11157754 
GO:0005515protein bindingISS-
GO:0008083growth factor activityIEA-
GO:0016563transcription activator activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043011myeloid dendritic cell differentiationIEAdendrite (GO term level: 10)-
GO:0001501skeletal system developmentISS-
GO:0002248connective tissue replacement during inflammatory responseTAS9639571 
GO:0002513tolerance induction to self antigenIEA-
GO:0001837epithelial to mesenchymal transitionTAS14679171 
GO:0007184SMAD protein nuclear translocationIDA15334054 
GO:0006468protein amino acid phosphorylationISS-
GO:0008219cell deathISS-
GO:0006917induction of apoptosisIDA15334054 
GO:0009887organ morphogenesisISS-
GO:0007050cell cycle arrestIDA14555988 
GO:0008284positive regulation of cell proliferationISS-
GO:0008354germ cell migrationIEA-
GO:0007435salivary gland morphogenesisIEP18080134 
GO:0016202regulation of striated muscle developmentISS-
GO:0006796phosphate metabolic processIDA10513816 
GO:0006754ATP biosynthetic processIDA10513816 
GO:0006954inflammatory responseISS-
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayIDA15334054 
GO:0019049evasion of host defenses by virusIDA15334054 
GO:0042306regulation of protein import into nucleusISS-
GO:0016481negative regulation of transcriptionIDA15702480 
GO:0051101regulation of DNA bindingISS-
GO:0042130negative regulation of T cell proliferationIEA-
GO:0030501positive regulation of bone mineralizationIEP17401695 
GO:0048298positive regulation of isotype switching to IgA isotypesIDA14988498 
GO:0030879mammary gland developmentIEA-
GO:0032740positive regulation of interleukin-17 productionIDA18453574 
GO:0031575G1/S transition checkpointIDA15334054 
GO:0030279negative regulation of ossificationIEA-
GO:0032943mononuclear cell proliferationIEA-
GO:0032967positive regulation of collagen biosynthetic processTAS9639571 
GO:0030308negative regulation of cell growthIDA15334054 
GO:0035307positive regulation of protein amino acid dephosphorylationIDA14555988 
GO:0043029T cell homeostasisIEA-
GO:0045893positive regulation of transcription, DNA-dependentISS-
GO:0045930negative regulation of mitotic cell cycleIDA14555988 
GO:0050680negative regulation of epithelial cell proliferationIMP16943770 
GO:0045066regulatory T cell differentiationIEA-
GO:0043932ossification involved in bone remodelingIEP17401695 
GO:0048535lymph node developmentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005796Golgi lumenEXP3457014 |9934696 
GO:0005576extracellular regionEXP9865696 |9934696 |11100470 
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixISS-
GO:0005615extracellular spaceISS-
GO:0005634nucleusIDA18040277 
GO:0005737cytoplasmIDA18040277 
GO:0031093platelet alpha granule lumenEXP3457014 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVRL1ACVRLK1 | ALK-1 | ALK1 | HHT | HHT2 | ORW2 | SKR3 | TSR-Iactivin A receptor type II-like 1-HPRD,BioGRID10716993 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor proteinTGF-beta-1 interacts with Amyloid-beta. This interaction was modelled on a demonstrated interaction between TGF-beta-1 from an unspecified species and consensus Amyloid-beta peptides.BIND12867422 
BGNDSPG1 | PG-S1 | PGI | SLRR1Abiglycan-HPRD,BioGRID8093006 |10383378 
BMP2BMP2Abone morphogenetic protein 2-HPRD11456401 
BMP3BMP-3Abone morphogenetic protein 3-HPRD9434787 
CCL3G0S19-1 | LD78ALPHA | MIP-1-alpha | MIP1A | SCYA3chemokine (C-C motif) ligand 3-HPRD8568261 
COL2A1ANFH | AOM | COL11A3 | MGC131516 | SEDCcollagen, type II, alpha 1-HPRD,BioGRID10085302 
CTGFCCN2 | HCS24 | IGFBP8 | MGC102839 | NOV2connective tissue growth factor-HPRD,BioGRID10457363 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated protein-HPRD11483955 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD7638106 |7798269 
Reconstituted ComplexBioGRID7798269 |8093006 
|9675033 
EIF3IEIF3S2 | PRO2242 | TRIP-1 | TRIP1 | eIF3-beta | eIF3-p36eukaryotic translation initiation factor 3, subunit I-HPRD,BioGRID9813058 
ENGCD105 | END | FLJ41744 | HHT1 | ORW | ORW1endoglin-HPRD12015308 
FCN1FCNMficolin (collagen/fibrinogen domain containing) 1-HPRD,BioGRID7686157 
FMODSLRR2Efibromodulin-HPRD,BioGRID8093006 
FNTAFPTA | MGC99680 | PGGT1A | PTAR2farnesyltransferase, CAAX box, alpha-HPRD,BioGRID8599089 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)-HPRD11970960 
ITGB6-integrin, beta 6-HPRD10025398 
ITGB8-integrin, beta 8-HPRD11970960 
LTBP1MGC163161latent transforming growth factor beta binding protein 1-HPRD,BioGRID8617200 |10930463 
LTBP3DKFZp586M2123 | FLJ33431 | FLJ39893 | FLJ42533 | FLJ44138 | LTBP-3 | LTBP2 | pp6425latent transforming growth factor beta binding protein 3-HPRD12062452 
LTBP4FLJ46318 | FLJ90018 | LTBP-4 | LTBP-4Llatent transforming growth factor beta binding protein 4-HPRD9660815 
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)-HPRD,BioGRID10652271 
MMP9CLG4B | GELB | MMP-9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Biochemical ActivityBioGRID10652271 
PZPCPAMD6 | MGC133093pregnancy-zone protein-HPRD,BioGRID7513640 
SNIP1FLJ12553 | RP3-423B22.3 | dJ423B22.2Smad nuclear interacting protein 1Affinity Capture-WesternBioGRID10887155 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)-HPRD15034927 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1-HPRD7935686 
TGFB2MGC116892 | TGF-beta2transforming growth factor, beta 2Two-hybridBioGRID11483955 
-HPRD11157754 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1TGF-beta-1 interacts with TGF-beta-R-I. This interaction was modeled on a demonstrated interaction between TGF-beta-1 from an unspecified species and human TGF-beta-R-I.BIND7852346 
-HPRD,BioGRID8235612 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)Affinity Capture-WesternBioGRID11157754 
-HPRD7935686 
TGF-beta-1 interacts with TGF-beta-R-II. This interaction was modeled on a demonstrated interaction between TGF-beta-1 from an unspecified species and human TGF-beta-R-II.BIND7852346 
TGFBR3BGCAN | betaglycantransforming growth factor, beta receptor III-HPRD7935686 
Affinity Capture-WesternBioGRID8106553 
TGFBRAP1TRAP-1 | TRAP1transforming growth factor, beta receptor associated protein 1Affinity Capture-WesternBioGRID11278302 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID1550960 
VASNSLITL2vasorin-HPRD,BioGRID15247411 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID11796824 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID11172812 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_CTCF_PATHWAY 2318All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_ERYTH_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_TOB1_PATHWAY 2114All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
SA_MMP_CYTOKINE_CONNECTION 159All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 167All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 2313All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 2616All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_DN 1913All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_UP 76All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
GALIE_TUMOR_ANGIOGENESIS 87All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_3 2823All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
LAMB_CCND1_TARGETS 1914All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN 1914All SZGR genes in this pathway
XU_CREBBP_TARGETS_DN 4431All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
WU_HBX_TARGETS_2_DN 1611All SZGR genes in this pathway
WU_HBX_TARGETS_1_DN 2314All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN 2113All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
WU_HBX_TARGETS_3_DN 139All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP 2823All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR 2013All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
GAVIN_PDE3B_TARGETS 2215All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
POS_HISTAMINE_RESPONSE_NETWORK 3222All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
GAUTSCHI_SRC_SIGNALING 86All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
MATZUK_CENTRAL_FOR_FEMALE_FERTILITY 2925All SZGR genes in this pathway
MATZUK_SPERMATOZOA 11477All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MIKKELSEN_DEDIFFERENTIATED_STATE_DN 77All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
DASU_IL6_SIGNALING_UP 5944All SZGR genes in this pathway
KANG_AR_TARGETS_DN 1912All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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