Gene Page: C3

Summary
GeneID  718
Symbol  C3
Synonyms  ARMD9|ASP|CPAMD1
Description  complement component 3
See related  HGNC:1318|MIM:120700|Ensembl:ENSG00000125730|HPRD:00400|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3-p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)9164946 
GO:0004866endopeptidase inhibitor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001798positive regulation of type IIa hypersensitivityIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9164946 
GO:0007165signal transductionTAS10085065 
GO:0006957complement activation, alternative pathwayEXP162484 
GO:0006957complement activation, alternative pathwayIEA-
GO:0006958complement activation, classical pathwayIEA-
GO:0006954inflammatory responseIEA-
GO:0050766positive regulation of phagocytosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP279011 |3052276 |6912277 
|12878586 |15199963 
GO:0005576extracellular regionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD4062888 
C2CO2 | DKFZp779M0311complement component 2-HPRD,BioGRID3546307 
C3AR1AZ3B | C3AR | HNFAG09complement component 3a receptor 1-HPRD,BioGRID11342658 
C5CPAMD4 | FLJ17816 | FLJ17822 | MGC142298complement component 5-HPRD,BioGRID11367533 
CD46MCP | MGC26544 | MIC10 | TLX | TRA2.10CD46 molecule, complement regulatory protein-HPRD,BioGRID1717583 
CFBBF | BFD | CFAB | FB | FBI12 | GBG | H2-Bf | PBF2complement factor B-HPRD,BioGRID8648130 |10610782 
|11367533 
CFHARMD4 | ARMS1 | CFHL3 | FH | FHL1 | HF | HF1 | HF2 | HUS | MGC88246complement factor H-HPRD,BioGRID9988761 
CFHR3CFHL3 | DOWN16 | FHR-3 | FHR3 | HLF4complement factor H-related 3-HPRD,BioGRID10622723 
CFHR4CFHL4 | FHR-4 | FHR4 | RP4-608O15.2complement factor H-related 4-HPRD,BioGRID10622723 
CFHR5CFHL5 | FHR-5 | FHR5 | FLJ10549 | MGC133240complement factor H-related 5-HPRD,BioGRID11058592 
CFIC3B-INA | FI | IF | KAFcomplement factor IBiochemical Activity
in vitro
Reconstituted Complex		BioGRID1401896 |8648130 
|9291131 
-HPRD1401896 |9291131 
CFPBFD | PFC | PFD | PROPERDINcomplement factor properdinReconstituted ComplexBioGRID3421908 |11513971 
CPN1CPN | FLJ40792 | SCPNcarboxypeptidase N, polypeptide 1-HPRD,BioGRID11939578 
CR1C3BR | CD35 | KNcomplement component (3b/4b) receptor 1 (Knops blood group)-HPRD9988761 |10382758 
-HPRD,BioGRID9988761 
CR2C3DR | CD21 | SLEB9complement component (3d/Epstein Barr virus) receptor 2-HPRD11684127 
-HPRD,BioGRID1830068|11684127 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)-HPRD,BioGRID2824652 
GPR77C5L2 | GPF77G protein-coupled receptor 77-HPRD11773063 
ITGAMCD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6integrin, alpha M (complement component 3 receptor 3 subunit)-HPRD,BioGRID4062888 |11073102 
ITGAXCD11C | SLEB6integrin, alpha X (complement component 3 receptor 4 subunit)-HPRD7512600 
Reconstituted ComplexBioGRID4062888 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD10608878 
MASP1CRARF | CRARF1 | DKFZp686I01199 | FLJ26383 | MASP | MGC126283 | MGC126284 | PRSS5 | RaRFmannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)-HPRD9719152 
OLFM4GC1 | GW112 | KIAA4294 | OLM4 | OlfD | UNQ362 | bA209J19.1 | hGC-1 | hOLfDolfactomedin 4-HPRD,BioGRID2824652 
PAPPAASBABP2 | DIPLA1 | IGFBP-4ase | PAPA | PAPP-A | PAPPA1pregnancy-associated plasma protein A, pappalysin 1-HPRD,BioGRID6203109 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140100All SZGR genes in this pathway
BIOCARTA_LAIR_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_CLASSIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_COMP_PATHWAY 1915All SZGR genes in this pathway
BIOCARTA_LECTIN_PATHWAY 1210All SZGR genes in this pathway
PID_ERB_GENOMIC_PATHWAY 158All SZGR genes in this pathway
PID_INTEGRIN2_PATHWAY 2918All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_REGULATION_OF_COMPLEMENT_CASCADE 1412All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_COMPLEMENT_CASCADE 3222All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 1610All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_MARKERS_DN 2014All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN 5135All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
TSUNODA_CISPLATIN_RESISTANCE_DN 5138All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN 5529All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HIF1A_TARGETS_UP 85All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN 6441All SZGR genes in this pathway
MANTOVANI_NFKB_TARGETS_UP 4333All SZGR genes in this pathway
MANTOVANI_VIRAL_GPCR_SIGNALING_UP 8654All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
LIANG_SILENCED_BY_METHYLATION_2 5334All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
BURTON_ADIPOGENESIS_5 12678All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
LIANG_SILENCED_BY_METHYLATION_UP 3218All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_UP 2411All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_UP 5636All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN 3125All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_DN 3018All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
DEMAGALHAES_AGING_UP 5539All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_DN 1713All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_PROGENITOR_UP 5830All SZGR genes in this pathway


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