Gene Page: UCP2

Summary
GeneID  7351
Symbol  UCP2
Synonyms  BMIQ4|SLC25A8|UCPH
Description  uncoupling protein 2 (mitochondrial, proton carrier)
See related  HGNC:12518|MIM:601693|Ensembl:ENSG00000175567|HPRD:03410|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005215transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006839mitochondrial transportIEAglutamate (GO term level: 6)-
GO:0006810transportNAS9196039 
GO:0015992proton transportTAS9054939 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneNAS9196039 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD,BioGRID10785390 
UCP2 interacts with 14.3.3-beta.BIND10785390 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideUCP2 interacts with 14.3.3-gamma.BIND10785390 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD,BioGRID10785390 
UCP2 interacts with 14.3.3-theta.BIND10785390 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideUCP2 interacts with 14.3.3-zeta.BIND10785390 
-HPRD,BioGRID10785390 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 9856All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
SAMOLS_TARGETS_OF_KHSV_MIRNAS_DN 6235All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP 8350All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP 11069All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER 5030All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_8HR 3931All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_FOXP3_CORE_DIRECT_TARGETS 1914All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
WILENSKY_RESPONSE_TO_DARAPLADIB 2920All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP 4126All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_DN 4530All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_DN 2013All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
DURAND_STROMA_NS_UP 162103All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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