Gene Page: VAPB

Summary
GeneID  9217
Symbol  VAPB
Synonyms  ALS8|VAMP-B|VAMP-C|VAP-B|VAP-C
Description  VAMP (vesicle-associated membrane protein)-associated protein B and C
See related  HGNC:12649|MIM:605704|Ensembl:ENSG00000124164|HPRD:09300|
Locus tag  RP5-1018E9.1
Gene type  protein-coding
Map location  20q13.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COPS30.920.90
EIF3M0.920.92
RBM340.920.90
RSL24D10.920.91
PSMD140.920.88
PSMA20.910.90
CCT40.910.91
MMADHC0.910.91
BXDC20.910.89
PPA10.910.84
Top 10 negatively co-expressed genes
AF347015.26-0.68-0.73
AF347015.2-0.67-0.72
AF347015.15-0.66-0.71
MT-CYB-0.66-0.71
AF347015.33-0.66-0.71
AF347015.8-0.65-0.70
MT-CO2-0.65-0.67
FAM38A-0.64-0.69
GPT-0.64-0.68
SLC6A12-0.63-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005198structural molecule activityIEA-
GO:0042803protein homodimerization activityIPI9920726 |16227268 |17540579 
GO:0019899enzyme bindingIPI17540579 
GO:0046982protein heterodimerization activityIPI9920726 |16227268 
GO:0048487beta-tubulin bindingIDA17540579 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0019048virus-host interactionIDA16227268 
GO:0030968endoplasmic reticulum unfolded protein responseIMP16891305 
GO:0045070positive regulation of viral genome replicationIMP16227268 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005794Golgi apparatusIDA16227268 
GO:0005789endoplasmic reticulum membraneIDA16227268 
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumIDA15372378 |16891305 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Reconstituted ComplexBioGRID12651853 
STX1BSTX1B1 | STX1B2syntaxin 1BReconstituted ComplexBioGRID12651853 
STX2EPIM | EPM | MGC51014 | STX2A | STX2B | STX2Csyntaxin 2Reconstituted ComplexBioGRID12651853 
STX4STX4A | p35-2syntaxin 4Reconstituted ComplexBioGRID12651853 
STX5SED5 | STX5Asyntaxin 5Reconstituted ComplexBioGRID12651853 
VAMP1DKFZp686H12131 | SYB1 | VAMP-1vesicle-associated membrane protein 1 (synaptobrevin 1)-HPRD,BioGRID9920726 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)-HPRD,BioGRID9920726 
VAPAMGC3745 | VAP-33 | VAP-A | VAP33 | hVAP-33VAMP (vesicle-associated membrane protein)-associated protein A, 33kDaReconstituted ComplexBioGRID9920726 
VAPBALS8 | VAMP-B | VAMP-C | VAP-B | VAP-CVAMP (vesicle-associated membrane protein)-associated protein B and C-HPRD9920726 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 3118All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_METABOLISM 6940All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN 6244All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_2 4231All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 14976All SZGR genes in this pathway
CHEOK_RESPONSE_TO_MERCAPTOPURINE_DN 2215All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
RAMASWAMY_METASTASIS_DN 6147All SZGR genes in this pathway
JIANG_VHL_TARGETS 13891All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
YOSHIOKA_LIVER_CANCER_EARLY_RECURRENCE_UP 4023All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1336396461A,m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-1431021081Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-183123612421Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-221/222126912761A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-31113119m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-376c126712731Ahsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-485-3p9298m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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