| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20030137 | HPV | ENSG00000103546.19 | protein_coding | SLC6A2 | No | No | 6530 | P23975 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC6A2 |
|---|---|
| DrugBank ID | DB04840 |
| Drug Name | Debrisoquine |
| Target ID | BE0000486 |
| UniProt ID | P23975 |
| Regulation Type | inducer |
| PubMed IDs | 12401623; 8740147; 5431666; 16126010; 8710929 |
| Citations | Joyce PI, Rizzi D, Calo G, Rowbotham DJ, Lambert DG: The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43, table of contents.@@Bryan-Lluka LJ, Seers H, Sharpe I: Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats. Naunyn Schmiedebergs Arch Pharmacol. 1996 Apr;353(5):536-44.@@Mitchell JR, Cavanaugh JH, Arias L, Oates JA: Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest. 1970 Aug;49(8):1596-604.@@Yi E, Love JA: Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia. Auton Neurosci. 2005 Oct 30;122(1-2):45-57. Epub 2005 Aug 25.@@Galli A, Blakely RD, DeFelice LJ: Norepinephrine transporters have channel modes of conduction. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8671-6. |
| Groups | Approved; Investigational |
| Direct Classification | Tetrahydroisoquinolines |
| SMILES | NC(=N)N1CCC2=CC=CC=C2C1 |
| Pathways | |
| PharmGKB | PA452616 |
| ChEMBL | CHEMBL169901 |
