Gene: UST

10090
2OST
uronyl 2-sulfotransferase
protein-coding
6q25.1
Ensembl:ENSG00000111962 MIM:610752 Vega:OTTHUMG00000016135 UniprotKB:Q9Y2C2
NC_000006.12
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.591e-1 (AD)  4.895e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2486416chr6:149014873 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2486396chr6:149000610 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11965507chr6:148874287 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7753810chr6:148791620 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM210A0.686
MAP3K130.658
PRMT60.655
BZW10.653
AZI20.651
SC5D0.65
MTCH20.647
DNER0.646
SOCS50.645
DTD20.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.494
OR4F29-0.44
CDA-0.27
CYP4B1-0.264
HIF3A-0.259
NFE2-0.251
CLEC4E-0.246
NPIPB6-0.24
C10orf105-0.239
CSAG1-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UST mRNA"22698814
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of UST mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of UST mRNA"19167446
D000082AcetaminophenAcetaminophen results in increased expression of UST mRNA26690555|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UST mRNA22100608
D000452AldrinAldrin results in increased expression of UST mRNA18579281
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of UST mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of UST mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of UST mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UST gene28505145
D002220CarbamazepineCarbamazepine affects the expression of UST mRNA25979313
D002994ClofibrateClofibrate results in decreased expression of UST mRNA22300585
D019327Copper SulfateCopper Sulfate results in increased expression of UST mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of UST mRNA"19167446
D003471CuprizoneCuprizone results in increased expression of UST mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of UST mRNA20106945
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of UST mRNA21791302
D002117CalcitriolCalcitriol results in increased expression of UST mRNA16002434
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of UST mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of UST mRNA23649840
C492448ICG 001ICG 001 results in increased expression of UST mRNA26191083
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UST mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UST mRNA23649840
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of UST mRNA21791302
D011374ProgesteroneProgesterone results in decreased expression of UST mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of UST mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of UST mRNA24780913
C059514resveratrolresveratrol results in increased expression of UST mRNA19371625
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of UST mRNA25895662
D012834SilverSilver affects the expression of UST mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of UST mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UST mRNA19933214
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UST mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of UST mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of UST mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of UST gene29154799
D014752Vinyl ChlorideVinyl Chloride results in increased expression of UST mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008146sulfotransferase activity-IBA21873635  
GO:0008146sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006477protein sulfation-TAS10187838  
GO:0030010establishment of cell polarity-IEA-  
GO:0030208dermatan sulfate biosynthetic process-TAS-  
GO:0050770regulation of axonogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2022923Dermatan sulfate biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal