Gene: DPP6

1804
DPL1|DPPX|MRD33|VF2
dipeptidyl peptidase like 6
protein-coding
7q36.2
Ensembl:ENSG00000130226 MIM:126141 Vega:OTTHUMG00000151511 UniprotKB:P42658
NG_033878.1
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.896e-1 (AD)  6.475e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3807235chr7:154685668 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9640200chr7:154470566 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs6464419chr7:154386240 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs10274025chr7:154270195 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLG30.972
SLC12A50.964
RBFOX20.961
CLSTN30.961
UNC13A0.96
ATCAY0.96
PAK10.958
ABLIM20.957
ARHGEF90.957
LRRC40.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.575
REST-0.574
YES1-0.566
HEY2-0.563
WWTR1-0.549
CNN2-0.529
RNF135-0.523
MYL3-0.518
SNHG18-0.517
CSAG1-0.517

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA]18700144
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DPP6 gene27153756
D001151ArsenicArsenic affects the methylation of DPP6 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to DPP6 promoter]19654925
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DPP6 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of DPP6 mRNA25181051
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DPP6 mRNA25607892
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DPP6 mRNA24982889
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of DPP6 mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene20938992
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DPP6 mRNA26924002
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DPP6 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene20938992
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of DPP6 mRNA21782745
D019833GenisteinGenistein results in increased expression of DPP6 mRNA21782745
D002112CalcifediolCalcifediol deficiency results in decreased expression of DPP6 mRNA17293106
D007854LeadLead affects the expression of DPP6 mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of DPP6 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of DPP6 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DPP6 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DPP6 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of DPP6 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DPP6 mRNA26924002
D009532NickelNickel results in decreased expression of DPP6 mRNA25583101
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DPP6 mRNA25607892
D009966OrphenadrineOrphenadrine affects the expression of DPP6 mRNA23665939
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of DPP6 mRNA18636392
C014153pirimiphos methylpirimiphos methyl results in decreased activity of DPP6 protein9204212
D010936Plant ExtractsPlant Extracts results in decreased expression of DPP6 mRNA23557933
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892
D011374ProgesteroneProgesterone results in increased expression of DPP6 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of DPP6 mRNA20726854
C017947sodium arsenitesodium arsenite affects the methylation of DPP6 gene28589171
D014212TretinoinTretinoin results in increased expression of DPP6 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of DPP6 mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of DPP6 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of DPP6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of DPP6 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DPP6 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA25607892

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008236serine-type peptidase activity-IEA-  
GO:0008239dipeptidyl-peptidase activityNOTIDA8103397  
GO:0015459potassium channel regulator activity-IDA18364354  
GO:0015459potassium channel regulator activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0072659protein localization to plasma membrane-ISS-  
GO:1901379regulation of potassium ion transmembrane transport-IDA18364354  
GO:1901379regulation of potassium ion transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0008076voltage-gated potassium channel complex-IDA18364354  
GO:0016021integral component of membrane-IDA18364354  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal