Gene: ZCCHC14

23174
BDG-29|BDG29
zinc finger CCHC-type containing 14
protein-coding
16q24.2
Ensembl:ENSG00000140948 Vega:OTTHUMG00000137655 UniprotKB:Q8WYQ9
NC_000016.10
PubMed|SNP Mapped
8   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.795e-1 (AD)  3.938e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9936994chr16:87469209 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs7192628chr16:87461252 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs11648852chr16:87460131 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs13334632chr16:87457213 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs12925472chr16:87447426 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs3748400chr16:87412233 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs34068017chr16:87407443-87407444 (GRCh38.p7)dupCnicotine dependenceIndel(Insertion and Deletion)
rs2241617chr16:87407442 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02896970chr16:87460610ZCCHC14Gene body3.980e-4Alcohol use disorders26763658
cg06545761chr16:87441441ZCCHC143'UTR5.087e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CREBBP0.899
EP3000.883
SKI0.882
ADNP0.879
ARID1A0.877
ZNF3840.874
MED13L0.874
CDK130.869
KDM3B0.869
USP240.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.694
OR4F29-0.649
NANOGNB-0.285
CD8B-0.26
KLRC2-0.246
OR6C74-0.24
SIM1-0.235
ODAM-0.225
FOXB1-0.224
IRX5-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of ZCCHC14 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of ZCCHC14 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZCCHC14 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ZCCHC14 mRNA24449571
D001151ArsenicArsenic affects the methylation of ZCCHC14 gene25304211
D001554BenzeneBenzene results in increased expression of ZCCHC14 mRNA19162166
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ZCCHC14 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZCCHC14 mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ZCCHC14 mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZCCHC14 mRNA"19150397
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ZCCHC14 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of ZCCHC14 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ZCCHC14 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ZCCHC14 mRNA26364221
C006780bisphenol Abisphenol A results in increased methylation of ZCCHC14 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ZCCHC14 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of ZCCHC14 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZCCHC14 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of ZCCHC14 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ZCCHC14 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ZCCHC14 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ZCCHC14 mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of ZCCHC14 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of ZCCHC14 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZCCHC14 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZCCHC14 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ZCCHC14 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of ZCCHC14 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZCCHC14 mRNA21179406
D007213IndomethacinIndomethacin results in increased expression of ZCCHC14 mRNA28201806
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZCCHC14 mRNA20938992
C029938nickel sulfatenickel sulfate results in increased expression of ZCCHC14 mRNA22714537
D010634PhenobarbitalPhenobarbital affects the expression of ZCCHC14 mRNA23091169
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ZCCHC14 mRNA17404688
C012526quercitrinquercitrin results in increased expression of ZCCHC14 mRNA25193878
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZCCHC14 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of ZCCHC14 mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZCCHC14 mRNA21570461
D014212TretinoinTretinoin results in increased expression of ZCCHC14 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of ZCCHC14 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ZCCHC14 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ZCCHC14 mRNA28973697
D014520UrethaneUrethane results in increased expression of ZCCHC14 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ZCCHC14 gene29154799
D014638VanadatesVanadates results in decreased expression of ZCCHC14 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZCCHC14 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of ZCCHC14 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0035091phosphatidylinositol binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (2012 Aug 1)Wang KSDrug Alcohol Depend