Gene: KANK1

23189
ANKRD15|CPSQ2|KANK
KN motif and ankyrin repeat domains 1
protein-coding
9p24.3
Ensembl:ENSG00000107104 MIM:607704 Vega:OTTHUMG00000019434 UniprotKB:Q14678
NG_016331.2
PubMed|SNP Mapped
32   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.317e-1 (AD)  6.373e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10758863chr9:742642 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs13286166chr9:741307 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs7027152chr9:741001 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs10739127chr9:737436 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10815562chr9:732302 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs4742236chr9:686753 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4742225chr9:677938 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs7033109chr9:614905 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7020705chr9:614803 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4610808chr9:614707 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7047247chr9:613932 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1962203chr9:613215 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10975395chr9:609829 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2804308chr9:607382 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2804304chr9:606439 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2641996chr9:595756 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2641997chr9:594697 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2642001chr9:593229 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2642002chr9:592718 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2642003chr9:592229 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2804280chr9:589511 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2641970chr9:581453 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2361089chr9:580868 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2804276chr9:580725 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2804275chr9:580319 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2641973chr9:580171 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2804266chr9:568384 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4740817chr9:561143 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10975061chr9:543631 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs2026075chr9:520886 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs1928415chr9:517715 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs7038366chr9:515616 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SASH10.887
AHNAK0.865
TJP10.851
MYO100.85
CYBRD10.849
KAT2B0.846
ZHX20.843
NOTCH10.841
RHOBTB30.84
EFCAB140.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTP1-0.51
ABCC12-0.501
MCHR1-0.496
RHO-0.494
AGMAT-0.477
ANKRD34C-0.475
MYOZ3-0.47
ADRA1D-0.469
KCNB2-0.467
CACNA1F-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KANK1 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of KANK1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of KANK1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of KANK1 mRNA28959563
D001280AtrazineAtrazine results in increased expression of KANK1 mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KANK1 mRNA18164116
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KANK1 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of KANK1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of KANK1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of KANK1 mRNA15336504
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of KANK1 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of KANK1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of KANK1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of KANK1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of KANK1 mRNA26577399
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of KANK1 mRNA19684285
D016572CyclosporineCyclosporine results in decreased expression of KANK1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of KANK1 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of KANK1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KANK1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of KANK1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KANK1 mRNA18164116
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of KANK1 mRNA25380136
D004237DiuronDiuron results in decreased expression of KANK1 mRNA21551480
D004317DoxorubicinKANK1 protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KANK1 mRNA22079256
D005485FlutamideFlutamide results in increased expression of KANK1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of KANK1 mRNA20655997|2364984
D005897GlafenineGlafenine results in decreased expression of KANK1 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of KANK1 mRNA17183730
C008261lead acetatelead acetate results in decreased expression of KANK1 mRNA22613225
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KANK1 mRNA"26251327
D016685MitomycinKANK1 protein affects the susceptibility to Mitomycin16217747
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of KANK1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KANK1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of KANK1 mRNA25380136
D009532NickelNickel results in decreased expression of KANK1 mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in increased expression of KANK1 mRNA22124623
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KANK1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KANK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KANK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KANK1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of KANK1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KANK1 mRNA28903501
C513428pyrachlostrobinpyrachlostrobin results in increased expression of KANK1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of KANK1 mRNA21632981
D012834SilverSilver results in decreased expression of KANK1 mRNA26014281
D012834SilverSilver results in increased expression of KANK1 mRNA27131904
D012906SmokeSmoke results in decreased expression of KANK1 mRNA21095227
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of KANK1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KANK1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KANK1 mRNA19684285|2129612
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KANK1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of KANK1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KANK1 mRNA16962184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KANK1 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of KANK1 mRNA23557971
D014212TretinoinTretinoin results in increased expression of KANK1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of KANK1 mRNA26745549
D014241TrichloroethyleneTrichloroethylene results in increased methylation of KANK1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of KANK1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of KANK1 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of KANK1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of KANK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KANK1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of KANK1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of KANK1 mRNA17963808
D014747VinblastineKANK1 protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in decreased expression of KANK1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of KANK1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16968744  18458160  19171758  19559006  22084092  26496610  
GO:0008013beta-catenin binding-IDA16968744  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0010977negative regulation of neuron projection development-IDA19171758  
GO:0030177positive regulation of Wnt signaling pathway-IDA16968744  
GO:0030336negative regulation of cell migration-IMP18458160  
GO:0030837negative regulation of actin filament polymerization-IBA21873635  
GO:0030837negative regulation of actin filament polymerization-IDA17996375  18458160  
GO:0035024negative regulation of Rho protein signal transduction-IMP18458160  
GO:0046627negative regulation of insulin receptor signaling pathway-IMP18458160  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP16968744  
GO:0090303positive regulation of wound healing-IMP22084092  
GO:1900025negative regulation of substrate adhesion-dependent cell spreading-IDA19171758  
GO:1900028negative regulation of ruffle assembly-IDA19171758  
GO:2000114regulation of establishment of cell polarity-IMP22084092  
GO:2000393negative regulation of lamellipodium morphogenesis-IDA19171758  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0032587ruffle membrane-IDA19559006  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (2012 Aug 1)Wang KSDrug Alcohol Depend