Gene: OR10A3

26496
HSHTPCRX12|HTPCRX12
olfactory receptor family 10 subfamily A member 3
protein-coding
11p15.4
Ensembl:ENSG00000170683 UniprotKB:P58181
NC_000011.10
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.494e-4 (AD)  1.768e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7942511chr11:7940384 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11041680chr11:7940250 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11041679chr11:7940205 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4758259chr11:7939583 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF30.656
SLC22A310.627
PRAMEF60.601
KRTAP25-10.587
CCER10.584
FOXR20.563
OR10Z10.555
PRAMEF70.553
C15orf530.551
CLDN250.549

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGSF11-0.302
LIFR-0.284
GPRC5B-0.282
LRP4-0.281
AQP4-0.279
SLC39A12-0.279
HEPACAM-0.274
CRB2-0.271
ELOVL2-0.271
LGR4-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OR10A3 gene27153756
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of OR10A3 mRNA"17331233
C006780bisphenol Abisphenol A results in decreased expression of OR10A3 mRNA25181051

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0004984olfactory receptor activity-IBA21873635  
GO:0004984olfactory receptor activity-NAS1370859  
GO ID GO Term Qualifier Evidence PubMed
GO:0007608sensory perception of smell-NAS1370859  
GO:0050911detection of chemical stimulus involved in sensory perception of smell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal