Gene: MAP3K4

4216
MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412
mitogen-activated protein kinase kinase kinase 4
protein-coding
6q26
Ensembl:ENSG00000085511 MIM:602425 Vega:OTTHUMG00000015968 UniprotKB:Q9Y6R4
NC_000006.12
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.719e-1 (AD)  6.277e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9458121chr6:161101446 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9355870chr6:161074626 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12110787chr6:161053934 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9295134chr6:161029496 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERCC30.93
MBD10.93
SEC24C0.927
OGT0.927
SF3B30.923
SUPT7L0.922
SMG70.921
AP1G10.918
EFTUD20.916
SEC16A0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.594
OR4F29-0.565
ASB4-0.306
SLC22A6-0.297
HORMAD2-0.296
PON3-0.292
PON1-0.287
LRAT-0.287
KLRC2-0.284
TRDN-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAP3K4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of MAP3K4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MAP3K4 mRNA17562736
D001151ArsenicArsenic affects the methylation of MAP3K4 gene25304211
C015001arsenitearsenite results in increased expression of MAP3K4 mRNA18191166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP3K4 mRNA19770486
D004958EstradiolEstradiol results in increased expression of MAP3K4 mRNA23094148
D004958EstradiolIGF1R mutant form promotes the reaction [Estradiol results in increased expression of MAP3K4 mRNA]23094148
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of MAP3K4 mRNA18692832
C044887beta-methylcholinebeta-methylcholine affects the expression of MAP3K4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MAP3K4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MAP3K4 mRNA29027980
C006780bisphenol Abisphenol A affects the expression of MAP3K4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAP3K4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAP3K4 gene28505145
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of MAP3K4 protein"23026733
D000074262Canola OilCanola Oil metabolite results in increased expression of MAP3K4 mRNA27363782
D002994ClofibrateClofibrate results in decreased expression of MAP3K4 mRNA16081524
D060729Coal AshCoal Ash results in decreased expression of MAP3K4 mRNA19000753
D019327Copper SulfateCopper Sulfate results in decreased expression of MAP3K4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MAP3K4 mRNA19770486
C017160cypermethrincypermethrin results in increased expression of MAP3K4 mRNA22528246
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MAP3K4 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP3K4 mRNA17379624
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of MAP3K4 mRNA27514524
D002945CisplatinCisplatin results in increased expression of MAP3K4 mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of MAP3K4 mRNA25016146
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MAP3K4 protein23301498
D005485FlutamideFlutamide results in decreased expression of MAP3K4 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of MAP3K4 mRNA20655997
C069837fullerene C60fullerene C60 results in decreased expression of MAP3K4 mRNA19167457
D005947GlucoseGlucose results in increased expression of MAP3K4 mRNA24659233
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of MAP3K4 mRNA]24659233
D007213IndomethacinIndomethacin results in decreased expression of MAP3K4 mRNA28201806
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MAP3K4 mRNA"24972896
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MAP3K4 mRNA25234470
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of MAP3K4 protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAP3K4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAP3K4 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in decreased expression of MAP3K4 mRNA19167457
C016030pantogabpantogab results in decreased expression of MAP3K4 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of MAP3K4 mRNA17450221
D010672PhenytoinPhenytoin results in increased expression of MAP3K4 mRNA20345932
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP3K4 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of MAP3K4 mRNA23557933
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of MAP3K4 mRNA18692832
D011374ProgesteroneProgesterone results in increased expression of MAP3K4 mRNA20864642
C045950propiconazolepropiconazole results in decreased expression of MAP3K4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAP3K4 mRNA24780913
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of MAP3K4 mRNA27514524
D011794QuercetinQuercetin results in decreased expression of MAP3K4 mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of MAP3K4 mRNA]24659233
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP3K4 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAP3K4 mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MAP3K4 mRNA27404394|2786577
D014212TretinoinTretinoin results in decreased expression of MAP3K4 mRNA16604517
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of MAP3K4 mRNA]15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MAP3K4 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of MAP3K4 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MAP3K4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAP3K4 mRNA19101580
D014635Valproic AcidValproic Acid results in decreased methylation of MAP3K4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MAP3K4 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of MAP3K4 mRNA21427059
D014639VanadiumVanadium results in decreased expression of MAP3K4 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAP3K4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004709MAP kinase kinase kinase activity-IDA9305639  9827804  
GO:0005515protein binding-IPI12052864  16157600  16256071  19270716  20221403  25241761  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0000186activation of MAPKK activity-IDA9305639  9827804  
GO:0001890placenta development-IEA-  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0010225response to UV-C-IMP9305639  
GO:0010468regulation of gene expression-IEA-  
GO:0019100male germ-line sex determination-IEA-  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0032212positive regulation of telomere maintenance via telomerase-IMP21531765  
GO:0035556intracellular signal transduction-ISS-  
GO:0043507positive regulation of JUN kinase activity-IDA9305639  
GO:0051973positive regulation of telomerase activity-IMP21531765  
GO:0060718chorionic trophoblast cell differentiation-IEA-  
GO:1900745positive regulation of p38MAPK cascade-IDA9305639  
GO:1904355positive regulation of telomere capping-IMP21531765  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9827804  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20624154Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (2010 Jul)Grucza RAAddict Biol
22309839Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)Wei JAddict Behav