Gene: ZNF407

55628
-
zinc finger protein 407
protein-coding
18q22.3
Ensembl:ENSG00000215421 MIM:615894 Vega:OTTHUMG00000179122 UniprotKB:Q9C0G0
NG_013216.1
SNP Mapped
6   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.063e-1 (AD)  4.622e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12956780chr18:74792062 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7229235chr18:74783036 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1974956chr18:74782885 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7228438chr18:74781358 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7228254chr18:74781205 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9947276chr18:74780733 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HERC20.909
GLYR10.897
DNAJC110.894
LDB10.889
BOD1L10.888
ASH1L0.881
PRKDC0.878
MTOR0.875
MAN2A20.874
RALGAPB0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.446
OR4F29-0.414
CSAG1-0.404
RAB13-0.381
ZNF114-0.376
FAM89A-0.371
FMO3-0.355
COPZ2-0.354
MYL3-0.354
MTRNR2L6-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF407 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ZNF407 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZNF407 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ZNF407 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ZNF407 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of ZNF407 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ZNF407 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of ZNF407 mRNA27594783
D008727MethotrexateMethotrexate results in increased expression of ZNF407 mRNA24449571
C568376MT19c compoundMT19c compound results in increased expression of ZNF407 mRNA21781307
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ZNF407 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ZNF407 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF407 mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0016569covalent chromatin modification-IBA21873635  
GO:0031060regulation of histone methylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleusCOLOCALIZES_WITHIBA21873635  
GO:0005634nucleus-IEA-  
GO:0035097histone methyltransferase complexCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal