Gene: SRPRB

58477
APMCF1
SRP receptor subunit beta
protein-coding
3q22.1
Ensembl:ENSG00000144867 MIM:616883 Vega:OTTHUMG00000159753 UniprotKB:Q9Y5M8
NC_000003.12
SNP Mapped
14   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.673e-1 (AD)  8.353e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6439442chr3:133821515 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1534166chr3:133818223 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1534165chr3:133818073 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1464937chr3:133817811 (GRCh38.p7)G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6439441chr3:133810750 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7650925chr3:133808325 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3817524chr3:133807559 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1107413chr3:133805873 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12490148chr3:133805129 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9853615chr3:133801137 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6794945chr3:133799619 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9881405chr3:133799354 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1830084chr3:133789620 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9843728chr3:133782563 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT20.942
GRPEL10.939
EMC30.933
CLPTM1L0.933
C1orf520.929
SLC35B10.929
DRG10.925
CCT80.925
YTHDF20.924
CCT70.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.666
OR4F29-0.606
P2RY14-0.338
KLRB1-0.316
IL18RAP-0.314
VNN3-0.313
CYSLTR2-0.295
CXCR2-0.295
C8orf74-0.291
MTRNR2L6-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SRPRB mRNA"22698814|2890350
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SRPRB mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SRPRB mRNA"23962555
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRPRB mRNA"19167446
D000082AcetaminophenAcetaminophen affects the expression of SRPRB mRNA17562736
D000638AmiodaroneAmiodarone affects the expression of SRPRB mRNA19483382
C547126AZM551248AZM551248 results in increased expression of SRPRB mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of SRPRB mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRPRB mRNA20127859
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SRPRB mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [SRPRB protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of SRPRB mRNA25181051
D002065BuspironeBuspirone results in decreased expression of SRPRB mRNA24136188
C584509C646 compoundC646 compound results in increased expression of SRPRB mRNA26191083
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of SRPRB protein"23026733
D002220CarbamazepineCarbamazepine affects the expression of SRPRB mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SRPRB mRNA27339419
D002994ClofibrateClofibrate results in decreased expression of SRPRB mRNA22300585
D002994ClofibrateClofibrate affects the expression of SRPRB mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of SRPRB mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRPRB mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of SRPRB mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of SRPRB mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of SRPRB mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SRPRB mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of SRPRB mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of SRPRB mRNA27638505
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SRPRB protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SRPRB mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SRPRB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRPRB mRNA17942748
D005001EthionineEthionine affects the expression of SRPRB mRNA19483382
D005485FlutamideFlutamide results in decreased expression of SRPRB mRNA24793618
C039281furanfuran results in increased methylation of SRPRB gene22079235
D005839GentamicinsGentamicins results in increased expression of SRPRB mRNA22061828
D005897GlafenineGlafenine results in increased expression of SRPRB mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SRPRB mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of SRPRB mRNA28201806
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SRPRB mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SRPRB mRNA"20188158
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of SRPRB protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SRPRB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SRPRB mRNA"25554681|2562005
D009853OmeprazoleOmeprazole affects the expression of SRPRB mRNA19483382
D010795Phthalic AcidsPhthalic Acids results in increased expression of SRPRB mRNA21061450
C006253pirinixic acidpirinixic acid affects the expression of SRPRB mRNA19483382
C045950propiconazolepropiconazole results in increased expression of SRPRB mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of SRPRB mRNA19483382
C059514resveratrolresveratrol results in increased expression of SRPRB protein25505154
D012822Silicon DioxideSilicon Dioxide results in increased expression of SRPRB mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of SRPRB mRNA19072884
D012999SomanSoman results in increased expression of SRPRB mRNA19281266
D013629TamoxifenTamoxifen affects the expression of SRPRB mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRPRB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRPRB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRPRB mRNA21354282
D019284ThapsigarginThapsigargin results in increased expression of SRPRB mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of SRPRB mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of SRPRB mRNA27760801
C066340tolcaponetolcapone binds to SRPRB protein19783845
C012589trichostatin Atrichostatin A affects the expression of SRPRB mRNA28542535
D014415TunicamycinTunicamycin results in increased expression of SRPRB mRNA22378314
D014635Valproic AcidValproic Acid results in decreased methylation of SRPRB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SRPRB mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19664239  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005881cytoplasmic microtubule-IDA23264731  
GO:0016020membrane-IDA22375059  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa03060Protein export
Reactome ID Reactome Term Evidence
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal