DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DSGGGS
Uniprot ID:
Q6NY19
Source protein:
KN motif and ankyrin repeat domain-containing protein 3
Source gene:
KANK3
Class:
DEG_SCF_TRCP1_1
Location:
509:514
E3 ligase:
BTRC
DEGRON score:
0.997
ASA_SCORE:
74.1167
COIL:
0.9222
CONS_SCORE:
0.4494
DSS_SCORE:
0.9165
HELIX:
0.0357
FCONS_SCORE:
1.0759
RIG_SCORE:
0.3662
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KANK3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGGGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96T37
RNA-binding protein 15
DEG_SCF_TRCP1_1
89:94
DSGGGS
BTRC
0.9617
More...
Q9Y462
Zinc finger protein 711
DEG_SCF_TRCP1_1
2:7
DSGGGS
BTRC
0.9877
More...
Q6NY19
KN motif and ankyrin repeat domain-containing protein 3
DEG_SCF_TRCP1_1
509:514
DSGGGS
BTRC
0.997
More...